The primary antagonist and creator of Leviathan's super-soldier program. He oversees the brainwashing and enhancement of spies into bio-soldiers. During the final confrontation at the auction, he attempts to kill Black Widow but is ultimately shot and killed by the Punisher.
Orion serves as the primary antagonist directly opposing Widow's mission objectives.
Orion's terrorist activities directly oppose S.H.I.E.L.D.'s security mandate under Fury.