Central figure of the Borgia family, entangled in political machinations and an incestuous relationship with her father. Object of obsession for her brothers, Juan and Cesare. After Cesare kills Juan, she marries Alfonso of Aragon but loves Cesare's lieutenant Perotto and becomes pregnant. Following Cesare's return and murders of her lovers, she accepts Cesare as her lover until the Pope arranges her marriage to Alfonso I d'Este to restore peace.