Knox functions as a recurring embodiment of the religious and constitutional forces opposing Mary's sovereignty.
The Scottish monarchy's survival and Mary's legitimacy are repeatedly threatened by Knox's campaigns and alliances.
Their opposition is primarily factional; the supplied episodes do not establish a sustained personal confrontation.
Knox leads opposition to the Scottish monarchy in S3E17 and later works with anti-Mary nobles in S4E12-S4E16, while Greer remains aligned with Mary.
They may share an anti-Mary objective while representing different centers of power, creating a potentially unstable alignment.
The supplied plot shows both men pursuing political influence around Mary's deposition, but does not document a direct personal clash.
Explore the full interactive character relationship map of Reign
Related entry on Wikidata (Q189937), public domain (CC0).