Watson's fiancée and later wife, a compassionate and resilient woman supporting his dangerous lifestyle.
Their marriage is a major personal commitment threatened by the conspiracy.
The plot states that Watson and Mary marry before traveling toward their honeymoon.
Mary becomes a direct target in Moriarty's campaign against Holmes.
Moriarty explicitly threatens Mary's life, and his men ambush the train carrying her and Watson.
Holmes makes a dangerous tactical choice to preserve Mary's life.
Holmes throws Mary from the attacked train into a river so that she can be rescued, preventing Moriarty's men from reaching her.
Explore the full interactive character relationship map of Sherlock Holmes: A Game of Shadows
Related entry on Wikidata (Q2731317), public domain (CC0).