A faded 50-year-old Hollywood fitness star dismissed from her television show due to age. After injecting an illegal serum, she creates a younger alter ego, Sue, with whom she must switch consciousness every seven days. As the duality fractures her psyche, she descends into a self-hating recluse suffering from rapid biological deterioration, ultimately meeting a violent demise at the hands of her own creation.
The nurse facilitates Elisabeth's access to the illegal serum.
Harvey employs and then discards Elisabeth based on industry ageism.
Elisabeth creates Sue as a rejuvenated temporal extension of herself.
Elisabeth knows Troy through industry connections
Elisabeth has an assistant who helps her
Elisabeth's former romantic partner
Elisabeth has professional interactions with the man in suit #3
Elisabeth has professional interactions with the man in suit #2
Elisabeth has professional interactions with the man in suit #1
Elisabeth auditions in front of the Assistant Casting Director
Sue inherits Elisabeth's career and public image
Elisabeth knows Oliver through industry connections
Elisabeth knows Fred through industry connections
Elisabeth competes with the Girl Auditioning for roles
Elisabeth encounters Man at Diner
Explore the full interactive character relationship map of The Substance