Member of the Doom Syndicate and Megamind's former villain associate. Breaks out of prison to test Megamind's loyalty, leads the group's crime spree, and initiates the city-launching scheme before being defeated by Megamind's reformed team.
They cooperate as members of the same villainous team.
Both characters are members of the Doom Syndicate and participate together in its criminal campaign against Metro City.
They share a past within the Doom Syndicate, but their goals now oppose each other.
The Doom Syndicate, including Lady Doppler, is described as a villain team that Megamind formerly belonged to.
Keiko becomes an active opponent of Lady Doppler's destructive plan.
Keiko joins Megamind's crew, assists in the plan against the Doom Syndicate, and helps defeat its members at the construction site.
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