Guy Watson (played by James Kirkwood) is a protagonist in The Wise Guy.
Mary (played by Mary Astor) appears in The Wise Guy.
Hula Kate (played by Betty Compson) appears in The Wise Guy.
Horace Palmer (played by George F. Marion) appears in The Wise Guy.
Ma Palmer (played by Mary Carr) appears in The Wise Guy.
The Bozo (played by George Cooper) appears in The Wise Guy.
Little Girl (played by Alma Lloyd) appears in The Wise Guy.
