Kate (played by Vera Farmiga) is a protagonist in Orphan.
Recovering alcoholic mother struggling with family trauma and Esther's threat. John (played by Peter Sarsgaard) is a protagonist in Orphan.
Father navigating marital strain and Esther's dangerous deception. Esther (played by Isabelle Fuhrman) appears in Orphan.
Titular manipulative girl with a dark secret, posing as a child but actually an adult woman. Sister Abigail (played by CCH Pounder) appears in Orphan.
Orphanage matron who initially vouches for Esther's innocence. Daniel (played by Jimmy Bennett) appears in Orphan.
12-year-old son who quickly suspects Esther is dangerous. Max (played by Aryana Engineer) appears in Orphan.
5-year-old deaf daughter who initially bonds with Esther. Dr. Värava (played by Karel Roden) appears in Orphan.
Latvian physician who treats Leena's injuries.