Dr. David Henning (played by Treat Williams) is a protagonist in Venomous.
A small-town doctor who attempts to address the deadly virus outbreak caused by genetically modified rattlesnakes escaping from a secret laboratory. Dr. Christine Edmonton Henning (played by Mary Page Keller) is a protagonist in Venomous.
Dr. Eric Foreman (played by Hannes Jaenicke) appears in Venomous.
Susan Edmonton (played by Catherine Dent) appears in Venomous.
Maj. Gen. Thomas Sparks (played by Tony Denison) appears in Venomous.
High-ranking military official representing the government's effort to conceal the laboratory incident and its deadly consequences. Gen. Arthur Manchek (played by Geoff Pierson) appears in Venomous.
Senior government official involved in the cover-up operations regarding the escaped genetically modified snakes. Billy Sanderson (played by Brian Poth) appears in Venomous.
Cindy Sanderson (played by Nicole Nieth) appears in Venomous.