Lessons in Chemistry: Season 1

Elizabeth Zott, a lab technician at the Hastings Research Institute, is disallowed by her superiors from developing her own research projects due to her gender and lack of a PhD. Elizabeth also applies her passion for chemistry to her cooking. After being forced to enter a workplace beauty pageant, she befriends Dr. Calvin Evans, the institute's star researcher. He agrees to transfer her to his laboratory so she can conduct her abiogenesis research independently. However, she abruptly leaves the

Flashbacks reveal that Elizabeth's thesis adviser had attempted to rape her during her doctoral candidacy exams, however she fought him off by stabbing him with a pencil. She is then told by the university that she can either admit fault for stabbing her advisor or rescind her candidacy, which she does. In the present, Elizabeth adopts a dog and names him Six Thirty. Their supervisor, Dr. Donatti, threatens Elizabeth with layoffs if Calvin's research does not qualify for a prestigious grant. Cal

Six Thirty's narration reveals his past as a former military dog and his guilt at Calvin's death. At the funeral, a grief-stricken Elizabeth is questioned by a journalist for the LA Times. Elizabeth returns to Hastings to find their lab emptied and their research in storage; Donatti attempts to recreate Calvin and Elizabeth's experiments and claim the research as his. To the dog's delight, Elizabeth realizes she is pregnant. Intending to continue her research, she begins to build a laboratory in

Elizabeth gives birth to a daughter, whom she names Mad. Still struggling with the loss of Calvin, she eventually finds emotional support in Harriet. For income, Elizabeth secretly serves as a consultant for fellow chemists facing research difficulties. She learns of Boryweitz and Donatti's theft of her and Calvin's research. She procures equipment for her kitchen-laboratory by impersonating Fran. Harriet's husband Charlie returns from the Korean War. She expresses her desire to continue her law

Mad begins work on her family tree, while Elizabeth works towards a job offer at another laboratory. Mad's teacher advises Elizabeth to move Mad to an advanced private school, and the cost leads Elizabeth to accept Walter's offer. Elizabeth and Walter butt heads with the sexist station owner, Phil, as she tries to make the show her own; ultimately, Supper at Six is a hit with the female audience. Mad, upset with the new status quo, starts looking into Calvin's past with the assistance of Reveren

Flashbacks reveal that Elizabeth's father was a preacher who faked miracles; his abuse and homophobia eventually drove her gay brother John to suicide. Mad continues looking for information on Calvin. Elizabeth invites Fran to a taping and hires her as chief of staff. Inspired by the burgeoning civil rights movement, Harriet organizes a protest along the freeway. Elizabeth initially caves to Phil's attempts at product placement after he leverages the pay of her crew, but after a talk with Harrie

In flashbacks, a young Calvin honed his chemistry skills, producing prayer candles and moonshine for the St. Luke's boys' home, and the bishop prevented his adoption. Calvin was consistently uncomfortable with people claiming to be related to him after he became famous. He also became pen pals with Wakely after the latter attended a guest lecture and discussed science, religion, and eventually his relationship with Elizabeth with him. When Mad and Elizabeth visit St. Luke's, the bishop feigns ig

Elizabeth is tasked with finding a replacement sponsor for Supper at Six. She meets with Avery Parker, Calvin's biological mother, who explains that she was forced to give Calvin away at birth. She had tried to adopt him and resorted to supporting him through the Remsen Foundation. Mad tells Elizabeth to continue doing science. Elizabeth selects Tampax as a sponsor, discussing menstruation on air, and quits the show on live TV. To Harriet's despair, the motion to build the freeway passes. Three