U.S. Marshal Jack Carter has a car crash while transporting his fugitive daughter Zoe, and ends up in the small town of Eureka. While waiting for repairs, he begins investigating a series of strange scientific phenomena, first is a missing boy and a destroyed RV, later the local cafe is trashed. During the investigation, Carter befriends some townsfolk including jack-of-all-trades Henry Deacon and Sheriffs Deputy Jo Lupo, but is hindered by Department of Defense liaison Allison Blake who has him
The video of the teenagers being attacked is now on the Internet, and Zoe has linked it to her homepage in an attempt to get some answers. Jack believes it is a drunk in a monkey suit, but a visit from Allison confirms it is real. Taggart is happy to have found something after so many years.
In the woods, Jo and Carter search for the creature. Stark tells Carter the information about the creature is classified. Jo and Carter find a gutted bear, and bag a claw they find in its stomach. Taggart and Fargo hunt the creature. Fargo is chased away.
The creature knocks out Taggart. As Allison and Jack change a flat tire, the creature attacks them. A gunshot sounds and the screen goes dark.
Taggart survives the creature's attack. He finds Fargo's broken glasses, and assumes he is dead. Allison has shot the creature and has it in a body bag at Henry's garage. A team from GD will collect it. Henry explains that the creature has Neanderthal DNA. The claw does not belong to the creature in the bag. There is a loud roar in the woods.
Fargo, tired and bruised, stumbles into the Sheriff's office. He says the creature is the "Missing Link" and he finds the creature that Allison shot, which is now at GD, is not the one that attacked him. Carter asks Stark about the creature. Stark says Taggart knows more since it was his project that created the creature and so Carter and Fargo leave to find him. As they leave, Stark says Taggart is one "stupid brilliant son of a bitch." In the woods, Jack and Fargo hear the creature roar as it
Jack and Fargo find Taggart, who is injured and incoherent. Taggart says his funding was stopped just as was on the verge of a breakthrough. Taggart says it was too early for human trials. Then, Taggart roars.
Taggart, now a creature, prepares to attack Carter. As Fargo makes a distraction, Carter shoots Taggart. At GD, Taggart appears human but is behaving like the creature. Fargo says he is now on gene therapy, and will be normal in a few weeks. Stark still will not explain what has happened. The team assume the threat is resolved but another creature is seen outside Jo's house.
Zeta and Roe intervene when a local biker gang harasses a child, who is the son of a wealthy robotics manufacturer. When the child is kidnapped after he invited them to his home, Ro and Zee are implicated in the crime.
Fleeing from Agents West and Lee, Zeta and Ro are lured to an abandoned candy factory by bounty hunter Rodin Krick, who plans to collect the reward by any means.
Ro takes a chance and appears on a Jenny Jones/Oprah like show because they claim to be able to reunite her with her brother.
Bucky needs Zeta and Ro's help to get his parent back from Dr. Tanner. Tanner has them working on a technological Fountain of Youth that's not quite perfected.