Following an unsuccessful yacht robbery, Harley Quinn is sent to Arkham Asylum, though she firmly believes that her boss and lover the Joker will break her out. A year later, her best friend, Poison Ivy, breaks her out during a prison break and tries to convince her that he does not love her. Despite Ivy's support, Harley's attempt to break up with the Joker fails after he convinces her to stay with him. The Riddler provokes the Joker into sending Harley to kill him before capturing her and Batm
Believing she has to join the Legion of Doom to prove herself as a supervillain, Harley attempts to crash one of their criminal enterprises with Ivy's help. However, they accidentally crash a bar mitzvah for the Penguin's nephew, Joshua. When the Joker learns of Harley's presence and arrives at the party, Harley struggles to dissociate herself from him and prove to the attending villains, Bane, the Scarecrow, and Two-Face, how much better she is doing without him. This is exacerbated by her atte
After the Joker hijacks a robbery she was committing, Harley realizes that she needs a crew to pull off legitimate heists and attract the Legion of Doom's attention. However, she struggles to recruit others to her cause due to her gender and past association with the Joker. After talking with the Queen of Fables, Harley decides she needs other downtrodden villains like her, and recruits Doctor Psycho, who was kicked out of the Legion by Lex Luthor for calling Wonder Woman and Giganta the "C-word
In search of a nemesis, Harley goes after Batman by stealing the Batmobile, but ends up with Robin, making her the laughing stock of the criminal underworld. Even worse, Robin appears on Tawny Young's talk show and lies about Harley agreeing to be his nemesis. After a failed attempt to get Superman to be her nemesis by kidnapping Lois Lane, Harley recruits King Shark into her crew, captures Robin, and threatens him into confessing he lied before revealing Young's talk show audience from behind a
While shopping around for a new lair, Harley is unable decide what her "brand" is and goes into a fourth degree brain-freeze. Ivy has Psycho bring them, Clayface, and King Shark into Harley's mind and meet with her consciousness. However, she accidentally triggers her mental defenses and locks them all in. While trying to find the "Emergency Exit" in her subconscious, Harley discovers her indecision comes from the belief her "origin story" was not her decision and that she altered her memory to
Harley's crew steals a mysterious device from Wayne Enterprises, but Clayface's arm gets severed and comes to life. Becoming depressed after learning Batman fails to see him as a friend, Commissioner Gordon interrogates Clayface's hand for the location of Harley's crew, but ends up bonding with it. While Harley, Clayface, and King Shark try to recover the hand, Ivy and Psycho seek revenge on an online personality called the Cowled Critic for slandering them. King Shark is beaten by police office
When the Queen of Fables is transferred from her U.S. Master Tax Guide Book prison to Arkham Asylum, Harley frees her so she can join her crew and help them steal a personal force field device from S.T.A.R. Labs. When the Queen slaughters an innocent family who witnessed them, however, the horrified crew kick her out as they are not willing to sacrifice innocent lives. They then use the force field device to steal a weather-controlling machine from Kord Industries to ransom Gotham, but the Queen
After Harley's crew steal Atlantean jewels, they are invited to join the Legion of Doom's headquarters, where Luthor reinstates Psycho. However, he secretly reveals to Ivy that he is not actually interested in Harley and will not let her join unless she joins as well. Ivy refuses and tries to warn Harley of Luthor's treachery. Suddenly, Aquaman breaks into the Hall of Doom and beats up several villains while seeking revenge for Harley's theft, but she tricks him into breaking an aquarium and foc
To Harley's surprise, the Joker congratulates her on joining the Legion of Doom, treating her as an equal. Harley reconciles with Ivy and promises to help her attack an environmentally unfriendly company called Planetwide Pavers. However, her crew are treated as lowly henchmen and Bane hires them to help him get revenge on a clerk for always getting his name wrong. Harley attends a dinner date with the Joker, intending to persuade him to convince Luthor to elevate her crew's status, but forgets
Depressed over her crew abandoning her, Harley returns home to her parents in Bensonhurst, Brooklyn, but becomes upset with her deadbeat father. Later that night, an assassin attacks them and kills Harley's grandmother before she defeats him. Her father claims he owes a loan shark money, so Harley beats him and his henchmen to force them to leave her father alone. Meanwhile, Ivy is trapped in a laboratory, but manages to use a dandelion to tell her sentient plant Frank to get Harley's help befor
Harley reunites with her crew to apologize and request their help in rescuing Ivy. They agree, but only for Ivy's sake. Meanwhile, the Scarecrow harvests Ivy's pheromones so he can use them to destroy Gotham before poisoning her with his fear toxin, sending her into a panic. While Borgman protects their bodies, Psycho brings the crew into Ivy's head, where Frank informs them that the only way to save Ivy is to destroy the thing she fears the most, which initially appears as the Grim Reaper. Harl
The Scarecrow crop-dusts fear toxin around Gotham's perimeter to force thousands of civilians towards the park with the murderous trees. As Batman tracks him down, the Justice League arrives to stop the trees. They assume Harley's crew is behind the attacks and attempt to send them to the Phantom Zone, but Ivy uses Wonder Woman's Lasso of Truth to prove them wrong. Suddenly, the Queen of Fables traps the League in her fairy tale book before using a beanstalk to send Harley and her crew to be att
Harley, her crew, Frank, and Kite Man hold an impromptu funeral for Ivy before joining forces with Batman to avenge her. However, Clayface inadvertently ruins the plan and gets the crew and Batman captured while Harley is forced into hiding. With his takeover largely complete, Joker spends the next week subjugating Gotham and torturing Batman and the crew, only to get bored. Hoping to help, the Scarecrow unmasks Batman, but Joker kills the former for ruining the "mystery". Harley revisits Ivy's