Dr. James' research projects are everywhere. DiDi attempts to secure a raise. Patsy's new initiative doesn't go down very well.
After Beverly's reassignment to another floor, new supervising nurse Patsy De La Serda (Mel Rodriguez) arrives at the ward and immediately clashes with the other staff members; Jenna's position as the ward's director of medicine is made permanent, much to her dismay; Varla Pounder (June Squibb), a patient suffering from bipolar disorder, causes trouble for the staff.
When a server crashes, it is disastrous for the staff. Didi steps on Dr. Stickley's toes.
A photo of Jenna's accidentally slips into a Christmas Card competition. Didi finds herself tempted by a visiting doctor.
DiDi deals with her younger sister, who's filling in on the ward and trying to impress Dawn. Dr. James encounters resistance to her research methods, an award goes to Patsy's head, and the staff are anxious to discharge a particular patient.
In the Season 2 finale, disturbing news about the hospice program is revealed by a whistle-blower, which could jeopardize the staff's future. Meanwhile, Dawn finds herself with two suitors; and DiDi discusses her salary issues with Dr. James.