Hurricane Katrina makes landfall in New Orleans. At Memorial Hospital, the doctors, nurses, and staff tend to patients and brace for the storm. A bridge going from one side of the hospital to the other looks like it might collapse, so Susan Mulderick orders Dr. Anna Pou to evacuate her team to the other side of the hospital.
While there is damage to Memorial Hospital, it is relatively minor, and the staff and patients think they've made it through the worst. Dr. Pou's husband wants her to go back home with him, but she refuses to leave the hospital because the situation is still an emergency. Soon after he departs, she learns the levees surrounding New Orleans are starting to break, and the waters are rising. She is distressed when she cannot reach him.
As the city floods, the hospital loses power. Susan Mulderick and the staff attempt to cope with the terrible conditions and prepare for an evacuation. Michael Arvin from corporate in Dallas is trying to help Memorial, but his superiors are seemingly uninterested. Mark and Sandra LeBlanc are trying to get back into New Orleans to help Mark's Mom, who is at Memorial.
Conditions continue to deteriorate. After Dr. Pou gets upset while caring for a patient, Dr. Horace Baltz advises her to take a rest. An official from the Department of Health arrives and tells Susan Mulderick that there will be rescue boats for them next morning. He also tells them to use colored armbands on patients to prioritize who should be rescued. As it gets dark, the Coast Guard wants to continue the helicopter evacuation, but Mulderick says it is too dangerous and shuts down the rescues
Mark and Sandra LeBlanc reach Memorial by boat and rescue Mark's mom. The decision is made to euthanize all pets, as they will not be considered for evacuation. Law enforcement officers arrive with boats and tell staff they need to get everyone out by five p.m. Susan Mulderick says no living patient will be left behind and advises Dr. Pou to speak with Dr. Cook about making patients comfortable.
Butch Schafer and Virginia Rider work for the state of Louisiana to determine what happened to the 45 people found dead at Memorial in the aftermath of Katrina. During their investigation, they speak to a number of staff members who believe that Dr. Pou gave some patients lethal doses of drugs to end their lives. Pou is offered a job at LSU, which she accepts. A CNN producer calls Pou to ask for the medical professionals' side of the story. Pou speaks with a Tenet attorney, who says she works fo
Due to the publicity about the investigation into Dr. Pou's alleged actions at Memorial after Katrina, she agrees to stop performing surgery. Toxicology results from eighteen of the dead patients show that nine tested positive for one or both of the drugs the pharmacist said he provided to Pou. One witness returns to tell Schafer and Rider that she saw Pou injecting several LifeCare patients and went with her to the door of Emmett Everett's room. Everett's wife asks Rider not to let powerful peo
Renowned forensic experts conclude that multiple patient deaths were homicides, but prosecutors with the Orleans Parish District Attorney's office - which now has jurisdiction in the case against Dr. Pou - are less enthusiastic than Schafer and Rider. Pou's lawyer convinces her to appear on 60 Minutes, where she comes across as sympathetic and credible, leading the coroner, Dr. Frank Minyard, to ask to meet with her. Minyard reveals he was close with her father, who helped him start his practice