The CIA tasks the Boys with assassinating Victoria Neuman, but the plan fails when her superpowered daughter Zoe discovers them and launches an attack. Ryan learns that Billy Butcher has only about six months to live due to the effects of V24. At CIA headquarters, Butcher reunites with Joe Kessler, an old ally who attempts to recruit him to fight against the Supes. Meanwhile, Homelander, increasingly frustrated with his aging and tired of his sycophantic followers, recruits Sister Sage, the smar
Butcher tells The Boys his remaining time to live and is kicked out. However, Butcher tracks them and helps them to spy on Sage, who is recruiting the alt-right Supe Firecracker at TruthCon. Butcher and M.M. fight, causing the former to leave. Their plan is thwarted when Sage, Firecracker, and Splinter intervene; Sage leaves and a fight ensues. Butcher returns and kills Splinter, and Firecracker flees in the aftermath. Guilty over his actions, A-Train gives Hughie and Annie January files exonera
Homelander introduces Sage and Firecracker as new members of the Seven and names Sage CEO, replacing Ashley, who is reduced to a figurehead role. Butcher and Kessler plan to kidnap Ryan, but when Butcher meets him, they instead spend time bonding. M.M. recruits A-Train as a spy, and he reluctantly agrees. Frenchie and Kimiko destroy a Shining Light Liberation Army cell, where a drugged Frenchie experiences hallucinations about his past and Kimiko is confronted by someone she knows. Annie confron
Daphne's plan to take Hugh Sr. off life support angers Hughie. Hughie and Kimiko obtain Compound V from A-Train for Hugh Sr. but are ambushed by the Shining Light. Hughie reconsiders and declines to inject his father with Compound V, but Daphne does so anyway. Annie meets with Singer to make a deal against Vought. M.M. and Butcher attempt to blackmail Firecracker but fail, and she publicly damages Annie's reputation by revealing her past abortion. Annie publicly assaults Firecracker, causing Sin
Butcher tells The Boys about a virus that kills Supes, obtained by Neuman.{{efn|As depicted in the Gen V (2023) season 1 episode "Sick".{{cite web |url=https://www.gamesradar.com/entertainment/superhero-shows/the-boys-season-4-episode-5-virus-gen-v-victoria-neuman/
The Boys discover that Tek Knight is hosting a party attended by Neuman and the Seven, and infiltrate it by disguising Hughie as Tek Knight's sidekick Webweaver. Tek Knight uncovers Hughie's identity and tries to mutilate him; the team enters the mansion to rescue him. During the chaos, M.M. shoots Sage in the head just before suffering a panic attack; A-Train rushes him to the hospital, and Sage survives due to her power of brain regeneration. Annie and Kimiko free Hughie and capture Tek Knight
Butcher frees Frenchie from jail to help Sameer develop the virus. M.M. relinquishes leadership of the Boys to Butcher and considers leaving with his family, but A-Train persuades him to stay. The team uncovers a plot to assassinate Singer involving a Supe shapeshifter. Homelander kills Webweaver, believing him to be the leak. Hughie visits Neuman to convince her to stop, but fails. Homelander sends The Deep and Black Noir II to attack The Boys, leading to a fight with Annie and Butcher until A-
While Butcher recovers, Mallory and Ryan visit him. Ryan is told about Homelander's crimes and urged to kill him, but he refuses, accidentally killing Mallory before leaving; Butcher then embraces Kessler's genocidal viewpoint. Homelander orders the Seven to purge Vought employees with damaging evidence about them, prompting Ashley to inject herself with V. As Frenchie works on the virus, The Boys guard Singer in a bunker, where they confront the shapeshifter; the real Annie arrives and kills he