Takeshi Hongo, a young scientist boasting of an IQ of 600 and a racing prodigy, is abducted and his body surgically remodeled by Shocker, an evil secret society plotting for global domination.
Hongo wins the championship, but the model who brings him his bouquet suddenly bares her fangs and attacks! With growing suspicion, Hongo investigates the woman's home, and finds it has been transformed into a lab.
Shocker tests their mysterious Scorpion Man by releasing their slave workers and telling them that they can have their freedom if they can escape within 10 minutes, but one by one they die at the Scorpian Man's hands.
At an amusement park's botanical gardens, people begin to go missing. The young boy Kenji's older sister Yukie gets snatched away, and he tries to tell someone that his sister was attacked by a giant King Sarracenian!!
While a series of strange earthquakes are going on, Hongo is contacted by his childhood friend and seismologist, Amemiya Chikako, who tells him, “Something is planning to cause a major earthquake.”
Former navy lieutenant-commander Sunada is attacked by the Chameleon Man. His aim is a submarine model in Sunada's possession that has secrets relating to a Nazi treasure concealed inside.
Kamen Rider, having fallen into a pit trap, loses his power in the secret room where no wind can reach and reverts back to his form as Hongo.
Hongo begins an investigation into the series of incidents where people who had glasses made at Kagemura's Optometry store have gone missing. But even Ruriko gets some lure glasses, and she disappears as well.
Cobra Man makes an attack on the gold vault, but when the pet dog of security guard Kondo barks at him, he drops his fangs! Seeking his fangs, he attacks Kondo.
Ritsuko Ayakoji of the Ayakoji Biology Research Institute, Shocker's collaborator, puts up advertisements for “Purchasing Animals” to gather animal blood and capture the people who bring in their pets.
Shocker has produced a new monster, Gebacondor, by assembling into one all the strong points of their previous monsters. But Gebacondor needs the lifeblood of young women.
Doctor Shirakawa has invented a death ray but tries to seal his invention away, while his aid Shibata conspires with Shocker and is remodeled into the monster Geckogeras, making secret plans to take the death ray.
To break through the Toyo Atomic Energy Research Laboratory's barrier, Shocker remodels pro soccer athlete Nomoto and produces the monster Tokageron with powerful kicking might.
Hongo saved Tokyo from a horrible fate at the hands of Shocker.But Hongo can not rest while Shocker's plans to conquer the world grows stronger every day. For justice, and for everlasting peace, Kamen Rider will continue his fight until the very end.
At the end of fierce fighting, Kamen Rider drives Sabotegron away. Sabotegron then uses Flowers of Mexico to attack Hayato and the Tachibana Racing Club.
Shocker gets their hands on the Pirazaurus whose poison can kill a giant dinosaur in mere seconds and begin to create a cyborg by combining it with a human.
Pirazaurus experiments with the powerful deadly gas, “Mist of Death,” at a gogo house. He launches his scheme to obliterate Japanese leaders with the Mist of Death as they spectate a pro wrestling match.
Shocker creates a missile base in the mountains and appoints the monster Hitodanger to defend it. After saving a boy from a Shocker attack, he fights Hitodanger to save Taki who went searching for the base.
For Shocker's plan to cause a tsunami in Hokkaido through submarine earthquakes, they send in the monster Kanibubbler to destroy all seismomitors.
Ichimonji, who has started an inquiry into a village thrown into panic by a gigantic catapillar creature, meets with Yoshioka who is looking for a missing professor, and together they begin a search for the professor.
In order for Shocker to make use of a growth drug developed by Yoshioka, Dokugander's adult form transforms into the deceased professor to trick the assistant professor Yoshioka.
An olympic swimmer disappears suddenly right before the eyes of his teammates, and a young man swimming in the ocean gets kidnapped by a monster who appears.
Shocker creates the monster Musasabidol to go after a new liquid fuel developed by Doctor Ookuma. Taki, who is visiting Hokkaido, discovers this plan, and after following Taki, Ichimonji confronts Musasabidol.
After a prisoner is immersed in the extract of poisonous mushrooms for one week, the monster Kinokomorgue is born.
Kinokomorgue declares, “Make him taste the fear of death!” and injects the captured Ichimonji with the antidote, returning him to his senses.
While the monster Hell Thunder enacts his plan to make an artificial antlion pit that tears main roads into pieces, the supreme commander Colonel Zol is dispatched from Shocker's branch in the Middle East.
Children are abducted by a suspicious man who calls himself a close friend of Kamen Rider. The man is the Shocker beast Mukaderas and he controls children with hypnotic radio waves for their scheme to turn them into members of Junior Shocker.
Shocker schemes to turn Tokyo Bay into a sea of flames by pouring in petroleum from industrial areas, equipping the monster Mogurang with an Electro Eye that he uses to capture humans.
Shocker seeks humans capable of withstanding 5000 volts of electricity to make a resource of Electric Humans they can use to assassinate important figures, so Kuragedal who can release high-voltage currents is sent to capture people.
Doctor Shimura's research that can revive ancient lifeforms catches the eye of Shocker, who steal the ancient trilobite ressurected from a fossil and infuse it with the blood of a blood-sucking cyborg, creating the monster Zanbronzo.