Ryan Mitchell, whose daughter Lindsey went missing years ago, also goes missing, and the team tries to connect his desire to help another couple with a missing son with his disappearance. Jack is trying to adjust to his new boss, Clark Medina.
Sara Kent, a rising executive, is abducted from a taxi after attending a rooftop party. The team also continues to learn to adjust to their new boss.
Alan Reynolds, a white-collar criminal, goes missing on his way to testify against a former associate and the team must find out why.
Will Duncan, the teenage son of a Secret Service agent, disappears and a long-festering secret that set a deadly chain of events in motion is discovered.
Martin is left on his own to solve the disappearance of Arianna Murphy, a victim's advocate from the scene of a double homicide, when Agent Medina diverts the rest of the team to investigate the abduction of a little girl from a mall.
Erin MacNeil, a bank manager, disappears and the team uncovers a dark secret during their investigations. Jack returns to his job as head of the department.
The squad discovers a shocking truth during an investigation of Chris Howe, a missing paraplegic recently injured in a car accident. The team also continues to adjust to normal with Jack back as the head of the department.
The team's latest case sends Jack and Sam to Los Angeles in search for Robb Simms, a man who went missing after his employee's funeral. Investigations in New York and California reveal a coast-to-coast mystery. Jack and Sam rekindle their relationship.
Doctor Erica Loza goes missing shortly after treating a patient and the team suspects a secret from her past is connected to her disappearance.
TV weatherman, Ben Coleman arrives at work bleeding from his side and the team tries to beat the clock to find out what that has to do with his disappearance.
A case about Daphne Stevens, a missing teenager last seen with her bipolar mother, gets twisted when the team finds she has a secret life. Jack and Sam's relationship hits a bump.
The team searches for Ken Gilroy, a bar owner, who goes missing shortly after his statue of St. Theresa cries. Brian's visit to Sam takes a new turn.
Elena is forced to face the consequences of her past as the team is put on the case to search for Bianca Gonzalez, Elena's former partner in the police force, who went missing during an undercover sting.
The team searches for Julie Fisher and Cate Conelly. The two neighbours were abducted from their homes. The case twists and turns when the agents learn the identity of the kidnapper.
Jay Lester, a man faking his identity and posing as a college student, disappears and the team must decipher his secrets in order to find him.
Kara Westfield and her son Hayden go missing from the local community centre after a fire alarm clears the building. The team tries to determine if any foul play is involved.
Zack Porter, a trial consultant goes missing and the team narrows down the list of suspects as they investigate his disappearance. Martin has a dangerous encounter involving a juror on a trial with which the missing person was recently involved. Sam and Jack learn to deal with Brian spending more time with Finn.
Justin Morgan, a psychologist, goes missing right after stopping a woman from jumping off of a building. The team believes that something in the life of the psychologist's brother might have played a role in his disappearance. Martin's relationship with Kim takes a spicy turn.
The suspect list keeps growing as the team investigates the disappearance of Lana Peters, a Russian matchmaker.
Keith Anderson, a billionaire's son, disappears after crash landing a small plane in the woods. Kim Marcus returns and her relationship with Martin develops.
Molly Samson, a journalist, goes missing. The team looks for her after her hardcore exposés are published in an online magazine. They begin to suspect a politician, the subject of one of her latest entries. Meanwhile, Brian remains in Sam and Finn's life.
17-year-old Stacey Tan, last seen on video being agitated by her abductor, goes missing and the team must do all they can to find her before it's too late.
Jack hesitates to assign the team to the case after Hannah's boyfriend, Shay Hanson (Kendall Schmidt) from Chicago disappears during his stay in New York.
After a late night dive, Derek Wilson disappears and the team tries to determine why. Danny and Elena prepare to make the next step in their relationship, their marriage.