Dee is suicidally depressed after realizing the guys were right about her looks and lack of talent. To snap her out of it, Dennis tries to find a man in her league while Charlie, Mac, and Frank encourage Dee to give her stand-up career another shot, which turns her into an overnight hit when the crowd loves her crude, self-deprecating jokes.
After Frank appears on Local Television advocating gun ownership, the rest of the gang takes a look at the ownership process and alternatives to find a common ground on this still heated issue.
In a clever jab at the show never being nominated for the Emmy Awards, the gang tries to make their bar worthy of a Philly Best Bar Award.
Dee and Charlie get roped into a pyramid scheme and try to get themselves out of it by scamming Ben the Soldier and others; Frank is stuck in a playground coil, but nobody rescues him because they think it's a trick.
Each Gang member gets his/her own day to do whatever they want with no complaints from the others, so Mac uses his day to give the others a religious experience, but they take a shine to his cousin "Country Mac" (Seann William Scott) who, unlike regular Mac, is honest about his homosexuality, doesn't push his religious beliefs on others, and treats the others with respect.
A robber bursts into the convenience store where the Gang are shopping and holds it up. While hiding in an aisle, Mac, Dee, Dennis, Frank, and Charlie each imagine how each of them would save the day.
After Frank announces that there's a flu epidemic in Philadelphia, the Gang quarantines themselves in the bar, where Frank becomes obsessed with purifying himself: he locks the others in a bathroom and overuses hand-sanitizer
A Flowers for Algernon-meets-Limitless parody finds Charlie being used as a test subject for a new intelligence pill that makes him smarter and more aware of his messed-up life, causing him to quit his janitor job. Meanwhile, Dee, Dennis, and Mac try to do Charlie's work but get sidetracked and high on gasoline; and Frank tries to bring Charlie back to his dimwitted self.
After creative differences over what constitutes tasteful nudity cause Frank to pull his money out of "Lethal Weapon 6" during filming, Mac, Dennis, and Charlie screen their rough footage for investors in hopes of raising enough capital to finish the production of their latest masterpiece.
The Gang invites their enemies to Thanksgiving dinner so they can forgive them for everything they've done to them.