Set one year after the finale of Season 8; J.D., Turk, Cox, Kelso and resident Denise return to Sacred Heart to teach med school while new med students Lucy, Drew and Cole are put through the wringer on their first day of school.
Lucy learns a hard lesson about what it takes to be a doctor after trying to save an alcoholic patient from his addiction. Meanwhile J.D. and Turk spot a potential love connection between Denise and the new med student Drew, as they play matchmakers with a little bit of help from Dr. Kelso.
J.D. and Drew learn a tough lesson in mentoring when Dr. Cox and Lucy show them that sometimes the student is the teacher. Meanwhile, Lucy decides to shadow Denise despite Denise's protests.
J.D. and Turk show up in costume at a med student's party which is not a fancy dress party. Meanwhile, Kelso bids a fond farewell to Ted and Gooch. Also, if Cole, Lucy, Drew and the gang want to go to the med student party, they must first complete 'final interview' on four patients, including a dying ex-soldier. Final Scrubs appearance of: Sam Lloyd as Ted.
J.D. still clamors for Dr. Cox's approval as he approaches his final day of teaching at Sacred Heart, Lucy searches within herself for the courage to perform a basic medical procedure (drawing blood) on a real human, and Denise and Drew make things official.
While Turk struggles to find a replacement best friend, a very pregnant Elliot offers advice and guidance to an over-worked and exhausted Lucy. Also, Cole finds out he could fail med school.
Before receiving their white coats, the med students of Winston University must figure out why they want to be doctors, and Lucy struggles with her answer. Denise gets a little relationship help from Elliot. Also, Cole reveals a secret Drew has been hiding.
Lucy finds couplings, dysfunctional and good, throughout the hospital. Meanwhile, Turk is angered after Perry makes him operate against his own judgement and the patient dies.
The reality of having a baby begins to settle in for both J.D. and Elliot while Lucy struggles with the reality of operating on people. Also, Perry doesn't know if he's ready to sign a will.
A student cheats on an exam leaving a cheat sheet in the toilets. Dr. Cox takes it out on the five students who briefly left the exam room detaining them indefinitely till someone confesses. Cole eventually confesses to save Lucy the humiliation, but she owns up to the group, who then cover for her. They all re-sit a new exam. Meanwhile, Drew reveals he is married (but estranged from his wife) and Denise makes a startling admission of her own.
Lucy takes her new assignment as hell week "team leader" a bit too seriously. Perry challenges Drew to stay away from his friends who arguably rely on him too much, and Dr. Turk feels threatened when an internationally renowned surgeon pays a visit. Eventually Drew steps in to save the study group and Turk accepts he can learn from the visiting surgeon.
Cole is told he has a malignant mole. Kelso gets negative results back after a few routine tests, he learns the hard way to put his ego in check. Meanwhile, Denise and Perry put Drew in the middle of their fight. Final Scrubs appearance of: Ken Jenkins as Kelso.
The med students at Winston University finally find something to be thankful for when Cole identifies his true calling in surgery, but he annoys Turk by shadowing him. Meanwhile, Drew realizes who the love of his life is after Denise decides to move in. Lucy finds the inspiration to become a doctor, after a former patient's son comes to say his final words to his deceased father.