Murdoch has left Toronto, and police work, for the Yukon. However, while in pursuit of fortune in the Klondike Gold Rush, he is drawn into a murder investigation (with the help of Jack London), and realizes his days as a detective are not yet behind him.
Religious tensions threaten to boil over when a Protestant Alderman is murdered during the Orange parade, and all evidence points to an Irish Catholic.
When the archaeologists behind an exhibition of recently excavated Egyptian antiquities begin dying under bizarre circumstances, rumours arise that a curse may be to blame.
While investigating an explosion, Detective Murdoch infiltrates an anarchist group led by American labour organizer, Emma Goldman.
With the close assistance of opera-loving Inspector Brackenreid, Detective Murdoch investigates the murder of a young opera singer acting as the understudy for a tempestuous diva.
James Pendrick returns to Toronto seeking investors for his latest invention – an electric car. When one of Pendrick's associates is murdered, Murdoch once again suspects the inventor may be a killer.
Detective Murdoch's investigation into the disappearance of a quiet librarian leads to a reunion with former love, Anna Fulford, and the discovery of a steamy underworld.
After saving his lover Anna from the Black Hand, Detective Murdoch bargains for her life. During his investigation into the murder of a shy librarian with a secret life, he encounters another young woman behaving seductively.
When a widely-disliked inventor is killed by a complex mechanical machine at a convention, Murdoch enlists Alexander Graham Bell's help to discover the killer's identity.
A high stakes card game involving Doctor Grace ends with the death of a player. Murdoch learns the winner of the game would be afforded the opportunity to die and be revived, in an attempt to contact the other side.
Murdoch is taunted by a deranged kidnapper who leaves talking dolls with personal messages directed at him at each crime scene. Guest appearance: John Tench as Alexander Graham Bell
Murdoch investigates when the captain of the Toronto Wellingtons hockey team is found dead in the locker room, shortly after fighting with another player.
Murdoch investigates the claims of a man who says his time travels to the future provided him with information that allowed him to stop crimes, while the New Year's Eve Policeman's Ball offers exciting personal possibilities for the 20th century.