After a government agent is murdered, McGarrett must identify the traitor in a scientific facility. Andrew Duggan and Steve Kanaly guest stars.
When an astrologer (Samantha Eggar) visits McGarrett to inform him of a murderer with a terrible temper, his antagonism lessens when her assumptions seem to be partly true. Tab Hunter guest stars.
An assassin who doesn't know he's an assassin? Sounds like a punch line from "The Naked Gun," but it's the story of this episode, where a diplomatic courier with a briefcase chained to his wrist is hypnotized and programmed to rig the case with a bomb. When Danno goes undercover to ferret out the assassination ring, he himself is brainwashed and programmed to kill McGarrett.
McGarrett is the lone hold-out in a trial where the guilt of the accused seems certain. Janis Paige, Lou Richards and Eugene Lion guest stars.
Hired by a crime-syndicate chieftain, a jet-setter and his girlfriend scheme to discredit McGarrett. Zohra Lampert and Richard Romanus guest stars.
Danny goes undercover in a neo-Nazi organization to investigate a violent hate campaign directed against a congressional hopeful. James Olson guest stars.
When a street robber claims that he stole King Tutankhamen's mask for fun, McGarrett suspects there is more to the case than simple robbery. Cyd Charisse, Rory Calhoun, Tim Thomerson and Robert Ellenstein guest stars. NOTE: Laura Sode-Matteson begins her regular series appearance as McGarrett's secretary, Luana.
McGarrett engineers a convict's (Brian Tochi) escape so he can rejoin his gang and provide information about their activities. Dane Clark guest stars.
Danno is stunned to learn that a former flame (Katherine Cannon) is apparently a shoplifter and a fugitive's (Burr DeBenning) girlfriend.
The death of a prominent politician reveals a strange love triangle. Sharon Farrell guest stars.
An evangelist (Keith Baxter) is assaulted by a man who claims the preacher is responsible for his wife's death. James Sikking and Jean Marsh guest star.
Two rival mobs attempt to take control of the disco scene in Honolulu.
The rival gangs are on the brink of all out war, and Five-O must struggle to stop them.
When a robbed bank vault shows no signs of break-in, an inside job seems the likely solution. McGarrett's trail of clues leads him back to the builder (Robert Reed) of the vault and his wife (Barbara Anderson).
Millicent Shand (Mildred Natwick) returns and claims that her niece's (Diana Scarwid) husband has faked his own death in order to get his hands on $500,000. Robert Vaughn and Eduard Franz guest stars.
A vacationing heiress (Tricia O'Neil) seems unconcerned when McGarrett warns her that someone (John Saxon) is after her ruby. Nita Talbot guest stars.
When a photographer takes a picture of a politician making a deal with an underworld figure, he tries blackmail. However, he is not prepared for the ruthless nature of the mobsters.
A private detective (Robert Loggia) is rescuing girls from prostitution, and using the opportunity to kill the pimps as well. John Larch and Kaki Hunter guest stars.
McGarrett must protect a physician (Fritz Weaver) suspected of drug peddling from a grieving father (Cameron Mitchell) whose son died of a drug overdose. Simone Griffeth guest stars.
The hunt for a high-rise killer is made more difficult for Five-O when a journalist offers to share his profits in exchange for the killer's story.
When a woman dies due to heroin packets bursting inside her and the Governor is implicated, McGarrett and Danno head off to Singapore to discover a smuggling operation.
Five-O must close the heroin smuggling operation to exonerate the Governor and catch the figures behind the scheme.