When Wo Fat steals toxins in an attempt to take out the leaders of Communist China, McGarrett must track him to Hong Kong.
In Hong Kong, Steve is caught by Wo Fat and mentally and physically tortured by being 'reconditioned'. He must beat these problems to save the day again.
McGarrett must solve a daring bank robbery committed during the King Kamehameha Day parade under the cover of a historic re-enactment. Clu Gulager and Michael McGuire guest stars.
Five-O discovers that the murders of prostitutes on the islands appears to be linked to an extortion racketeer. Elaine Joyce and Ned Beatty guest stars.
When Five-O discovers that five murder victims were killed by radiation poisoning, they must track down the one person they all came in contact with before it claims another victim. Pat Hingle, John Hillerman and Alan Fudge guest stars.
A lack of information hampers Five-O's search for an international assassin. Amanda McBroom and Cliff Gorman guest stars.
A forger (Kevin McCarthy) steals over $14,000 from the Five-O team, then targets a bank and the U.S. Navy. Elaine Giftos and Anthony Ponzini guest stars.
The annual Transpacific Yacht Race from California to the islands is the scene of mutiny and murder. Amanda McBroom guest stars.
Rather than accept parole, a prisoner escapes to prove he did not kill his wife. Zohra Lampert, Jack Kelly and Lyle Bettger guest stars.
A mobster who staged his own "death" to elude a conviction returns to reclaim his former syndicate. Meg Foster, George Wyner, Seth Sakai and Thayer David guest stars.
The daughter of a crime lord is murdering her father's appointed successors. Irene Yah-Ling Sun, Paul Hecht, Kwan Hi Lim and Clyde Kusatsu guest stars.
A vengeful ex-convict (Don Stroud), partially paralyzed by a police bullet, begins killing police officers. Gerald McRaney and Seth Sakai guest stars.
An avenging man (Rich Little) pursues a drug dealers who contributed to a former addict's death. Milton Selzer, Don Knight and Mel Ferrer guest stars.
McGarrett is a victim of an elaborate plot to frame him for murder of his girlfriend (Camilla Sparv). Jonathan Goldsmith and Danny Kamekona guest stars.
The Five-O team helps a Tokyo cop smash a ring that smuggles handguns into Japan. France Nuyen, Manu Tupou, Edward James Olmos and Roger Perry guest stars.
McGarrett fears a rapist-murderer (William C. Watson) roaming Oahu will find a girl (Laurie Prange) lost in the mountains before Five-O can rescue her. NOTE: Final series appearance of Glenn Cannon in the role of District Attorney John Manicote.
The head of a gambling syndicate kills a police officer in a hit-and-run auto accident. John Ritter, Nehemiah Persoff guest stars. NOTE: Final series appearance of Amanda McBroom in the role of HPD officer Sandi Welles.
An elderly man (Barnard Hughes) wires himself to a bomb and takes hostages to halt his home's demolition. Sharon Farrell and Richard Davalos guest stars. NOTE: Jimmy Borges in the role as himself.
A singer (Pamela Franklin) held for ransom is shipwrecked with her kidnappers (Christopher Connelly and Stephen Young|Stephen Young]]) off the island of Kauai.
Mainland gangster needing a place to launder money tries to force a football-club owner to sell his team. Dane Clark and Jo Anne Worley guest stars. NOTE: Lynne Kimoto as McGarrett's secretary, Lani.
The kidnapping of an oceanographer's brother is linked to the recovery of a computer. Pat Hingle and Mel Ferrer guest stars.
The Five-O team are finding a lot of resistance while searching for a cowboy at the rodeo grounds where he was working. George DiCenzo and Nicholas Hammond guest stars
The team track down the daughter (Jessica Harper) of a Los Angeles lawman (Biff McGuire) who has taken refuge with a religious cult after she is framed for murder. However, the real person (Paul Shenar) that was responsible for the crime is also searching for her.
A hang glider's theft of a historical exhibit catches the attention of crooks planning a heist of Army rifles. Lee Purcell, Charles Frank, Allan Rich guest stars.