With Pride on administrative leave following Mayor Hamilton's takedown, he's replaced by a by-the-book Supervisor Paula Boyd (Becky Ann Baker). Meanwhile, the NCIS team investigates a vehicular homicide involving stolen radioactive nuclear waste. Later on, they discover that the perpetrator is trying to make a dirty bomb.
While Pride's packing for a father/daughter fishing weekend, a mysterious woman (Dendrie Taylor) shows up at headquarters with intel about a serial killer targeting women on the Gulf of Mexico. Things take a dramatic turn when the woman kidnaps Pride to get him to listen to her.
The team joins forces with FBI Director Isler after a Russian operative with intelligence on sleeper agents disappears; Tammy partners with former sleeper agent Eva Azarova to assist in the investigation.
Pride and his team investigate the murder of a petty officer at the scene of a 150-year-old cold case. Pride later thinks this could be a copycat murder. Gregorio reveals that she has a fear of ghosts when she discovers that the case is connected to a séance.
Pride and his team help Sebastian out when he's put on administrative leave after a foot chase of a high-value target ends with Sebastian shooting what appears to be an innocent bystander.
The team investigates the murder of a petty officer who was killed in a mysterious way. They struggle to find evidence as the perpetrator covers their tracks. LaSalle's father visits New Orleans to discuss taking over his family business.
Patton is forced to put himself into an uncomfortable situation by working with his ex-wife (Kelly Hu) when her clinical trial for injured veterans gets hacked by expert hackers.
Wade's son Danny calls Pride for help after he's attacked at his girlfriend's house and she goes missing. The director of NCIS mandates that Pride meet with a therapist to discuss his process for solving cases.
Pride second-guesses evidence suggesting homeless kids are the suspects in the murder of a petty officer.
Pride is livid when he finds out that ex-Mayor Hamilton is trying to make deals to get out of prison. The team race to find the identity of his partner to keep Hamilton in prison.
Pride is forced to put Percy on the sidelines when a robbery case involving a high-speed chase turns deadly, as the investigation leads to her former ATF partner.
While Pride is away, Sebastian takes lead of the team and is dealt a case involving an old classmate accused of murdering her business partner. The NCIS headquarters computer system gets hacked by an expert hacker.
Pride and his team investigate the murder of a petty officer who worked at a local nightclub bar that he and his mother used to play at weekly. Gregorio suspects it might be drug-related. LaSalle receives news that his father has died and he's the executor of his estate and his company.
It's Mardi Gras in New Orleans and Pride's team investigates the murder of a petty officer who was trying to help a Syrian refugee, previously falsely accused as the killer, from being recruited to a terrorist group threatening interim Mayor Taylor's life. Wade helps Taylor's ultimately successful campaign for the special election.
FBI Special Agent Raymond Isler asks Pride for help with an off-the-books opioids theft investigation he is personally invested in. Percy is sent undercover as a getaway driver with Isler as the muscle for a job tied to the case.
Pride and his team investigate the disappearance of a congressional aide after she was ambushed by men posing as agents. LaSalle makes difficult decisions on behalf of his brother.
The team investigates the murder of a Navy captain and follow her footsteps along with her father in the search for a lost 200-year-old fleur de lis.
Pride, Gregorio and Sebastian travel to South America to help out with one of Pride's colleagues whose Army mission gets compromised. Meanwhile, Percy receives a job offer at the FBI and is hesitant to tell Pride.
Percy and LaSalle go undercover at a high-stakes, underground poker game after the organizer targets players with access to a naval research laboratory. Also, Laurel Pride (Shanley Caswell) visits her dad during spring break to discuss options after her upcoming graduation. Note: This episode marks the final appearance of Shalita Grant as a series regular.
Pride and his bar patrons, including Sydney Halliday (Riann Steele) who's visiting Pride after leaving the Army, are held hostage by a group of volatile thieves.
The team investigates the brutal murder of a pilot, which bears a striking resemblance to a case used in Gregorio's profiling training. Soon Gregorio discovers that her old professor is actually a serial killer - and that she's the next target.
When a scathing article criticizing Pride's use of excessive force is published, the team gets concerned with the classified files used as sources and Rita returns to warn Pride that this is part of a plot to bring him and the NOLA NCIS office down.
As Pride faces an indictment for abuse of power and discovering the person behind it all, he recruits an off-the-books team to help him figure out why he's been targeted - and what the endgame is.
The NCIS team races against time and a dangerous, well-connected opponent to prevent a terrorist attack on the New Orleans Tricentennial Fleet Week; LaSalle makes a shocking discovery about his family's business (though he initially believed that it was a stall tactic from the opponent, only to later find out how real it turned out to be).