As Pride fights for his life in the ICU, the rest of the team searches for Amelia Parsons before she can finish Pride off.
The team is on the hunt for a group of trained killers responsible for bringing an IRA bombmaker to New Orleans; Pride is offered a promotion to Regional Special Agent in Charge and as he considers it, Agent Hannah Khoury arrives at the office as Pride's replacement.
The investigation into the murder of a Navy commander attached to an international summit gets complicated when a key figure in the investigation gets close to Sebastian; Pride adjusts to his new position as Regional SAC.
The NCIS team investigates the murder of a petty officer who was found under a shrimp fishing boat. Meanwhile, Pride assists LaSalle in his late father's business which is being investigated for Tax fraud by the IRS.
When a box of Pride's childhood mementos is found in a storage container where four white supremacists were murdered, the investigation leads Pride to face the past and uncovering his father's secrets.
Pride receives news that his assistant had escaped from a kidnapper and the NCIS team investigates. They discover that the kidnapper was interested in harvesting her organs to sell them on the black market. Meanwhile, Pride turns to an ally to help him cope with his near death experience.
The team investigates a car bombing near the French Quarters which leads to a series of bombings around New Orleans. Meanwhile, Gregorio discovers that Hannah has a daughter.
The team places Mateo Diaz, a high school gang member turned informant, in protective custody while they investigate the murder of his junior reserve officers' training corps instructor. Pride needs his brother's help to gain Mateo's trust.
After a Navy contractor is mysteriously murdered, the team begins their investigation and unearths evidence that the victim lived two separate lives for decades.
Pride is taken by two masked men during a sunrise jog and forced to perform a series of tasks for them in order to save Wade and his father, who are being held captive.
Following Pride's father's death, the NCIS team looks into the people responsible. Pride suspects that former Intelligence agents might be involved.
While undercover, Gregorio joins a social club for military wives after one of the members is contacted by an ex-boyfriend. a wanted fugitive on the FBI Most Wanted List.
The NCIS team investigates the disappearance of a Biologist who is carrying a deadly biological weapon after a mass shooting at their lab. Meanwhile, Gregorio and Sebastian bicker about each other’s habits as new roommates. Also, Hannah returns to New Orleans early following a personal leave.
Pride and the team reunite with conspiracy journalist Oliver Crane after the source for his latest vigilante story is murdered. Also, Hannah’s former partner, Liam Somers, surprises her in New Orleans and shares a shocking revelation about an old case.
The team investigates a series of murders at a local construction site known for creating special chemicals for sea walls. Meanwhile, Hannah’s investigation into finding her former partner hits new heights.
Hannah is forced to put her daughter in protective custody after she discovers that a terrorist that she was tracking down when she was in the CIA resurfaces and is after her and her family. Meanwhile, Pride and the rest of the team investigates the terrorist's whereabouts.
Pride returns to the New Orleans office after he discovers that he had been re-assigned. Meanwhile, the NCIS team investigates the disappearance of a petty officer.
The NCIS team investigates the murder of Patton's friend, a former Navy Seal gunned down in a drive-by shooting, while he watched.
Pride and his team investigate the murder of a person from a wealthy family. Roadblocks begin to arise when the family’s lawyer begins to cover-up for them and try to rule the death an accident.
Elvis Bertrand asks for Pride to prove his daughter's innocence when she is connected to a murder case that NCIS is investigating.
The team investigates the murder of a doctor who was killed in what was supposed to look like an accident. Gregorio begins to grow suspicious that one of the victim's father might be involved. Meanwhile, Hannah’s husband re-emerges and asks for Pride's help on new intel on Apollyon.
Pride and his team investigate a series of bombings all across New Orleans when one killed over 5 in a museum.
Time is of the essence when an FBI operation to catch the Apollyon leader goes terribly wrong and Pride and LaSalle are forced to rescue FBI Special Agent Isler who is being held captive in South Ossetia.
Hannah and the rest of the team race against the clock to rescue Pride from the Apollyon leader and to not reveal confidential information. Meanwhile, while being held captive and drugged, Pride begins to experience hallucinations at various points and alternate timelines of his life.