Set a few weeks after Mardi Gras, New Orleans struggles with the effects of COVID-19 as the pandemic begins to spread mercilessly throughout the world. Pride, dealing with the ramifications of the statewide order to close all restaurants and bars, sends Gregorio and Carter to investigate a suspicious death aboard a humanitarian ship offshore, but while on board they learn that some of the crew members are infected with the deadly disease. Meanwhile, Wade is overwhelmed by the high volume in the
Carter and Gregorio survive a fiery explosion aboard a COVID-19 infested ship searching for evidence of a suspicious death. Meanwhile, Pride reunites with Rita who reveals some shocking news. Wade helps a woman find her brother's body after he dies from COVID-19. Patton and his goddaughter get into a heated argument about her future after high school.
Pride and his team investigate the murder of a fellow New Orleans police officer. Pride soon discovers that the victim was being investigated for using excessive force while on the job. Gregorio begins to feel the effects when she begins a new relationship.
The NCIS team continue their investigation into the murder of an officer who was about to blow the whistle on police misconduct within NOPD. After he and Rita are swatted by one of the subjects of the investigation, Pride is forced to get creative to finally get rid of the dirty cops, while simultaneously reflecting on his own misconduct in the past. Meanwhile, as COVID-19 continues to overwhelm the system, Wade finally addresses the toll it's taken on her.
Pride and his team investigate the death of a person who held the key to a top-secret high-tech battery. Rita gets assigned to a civil lawsuit case involving someone who was wrongly fired.
Pride and his team continue to investigate a mysterious torpedo from a submarine that terrorizes the people of the Gulf Coast. Meanwhile, with Gregorio's relationship with her girlfriend growing stronger, Sebastian fears that she might move out.
When a marine psychologist is found dead in an alleyway, the team discovers the cause is something bigger than the victim's counseling session. Sebastian is helping a witness to get back on her feet after he finds out she's homeless and her child is in protective custody.
As Pride and the team continue the investigation of an officer's assault and the murder of her therapist, NCIS zeros in on a prime suspect who's been working the system for years. Carter and his mother talk about how they'll move forward after a past mistake, and Sebastian begins a promising new relationship.
Pride and the team are on the hunt for a kidnapped 14-year-old girl and discover that her father, who'll soon have custody of her, is a radical survivalist living off the grid.
When a petty officer is shot down by a sniper, Pride and NCIS hunt down the killer, only to find that he may not be acting alone. Rita tells Pride that she's been offered a compelling job in Kansas City.
Sebastian's life is in danger when a criminal he put behind bars escapes police custody. Carter is tasked with keeping Sebastian in protective custody, and Carter and Hannah's flirtation is fun gossip fodder for Gregorio and Sebastian.
After a Molotov cocktail is hurled at Pride's bar, evidence leads to his old nemesis Sasha Broussard (Callie Thorne) who's been keeping a secret that will affect his life forever. Gregorio uses her profiling skills on Hannah and Carter with shocking accuracy.
The team investigates the deadly bar bombing and impending criminal turf war involving Sasha Broussard. While Pride must come to terms with having Connor in his life, Carter and Hannah work to define their new relationship.
As Pride directs the team to link Sasha to the recent attacks in New Orleans, he must help Connor come to terms with who his mother really is. Carter and Gregorio search for a stolen highly trained military dog. Also, Pride and Rita make an important decision about their wedding.
As Pride and Rita plan their wedding, the FBI arrests Connor (Drew Scheid) in connection with the bar's firebombing as a means of getting to his mother, Sasha Broussard (Callie Thorne), and Rita may be the only person who can save them. Gregorio moves out of Sebastian's house.
On the eve of Pride's wedding to Rita and Connor entering witness protection, Pride must find who attacked Jimmy (Jason Alan Carvell) and Connor (Drew Scheid) while also figuring out Sasha's (Callie Thorne) ulterior motives regarding their son.