Pride is forced to suspend Hannah from duty after she breaks protocol following a joint operation with the FBI to take down a white supremacist. Meanwhile, Pride and Rita visit Pride's mother who is revealed to be suffering from Alzheimer’s disease.
A Navy pilot discovers an unidentified flying object shortly before crashing. Meanwhile, Pride suffers through nightmares and insomnia from being kidnapped and drugged. LaSalle goes to Mobile, Alabama, to locate his missing brother.
Pride visits New York City after he learns newly acquired DNA evidence is linked to a cold case from 20 years ago when he worked at the Jefferson Parish Sheriff's office.
The team uncovers a sinister plot by a private detention center contracted by the government to house undocumented immigrants; Lasalle and Sebastian travel to Alabama to search for Lasalle's missing brother.
A Navy lieutenant, Max Landry (Michael Ocampo), asks the New Orleans field office for help when he suspects that his girlfriend is actually a spy. Meanwhile, LaSalle faces another devastating setback when he finds his brother's body in Alabama.
LaSalle hopes to avenge his brother's murder by tracking an opioid drug ring in Alabama which he believes is responsible. While investigating a remote cabin, LaSalle is shot. He's flown to a hospital where he dies, leaving Pride and the team devastated. When Pride assists with the case, he meets and later arrests a man who was involved in the shooting.
A movie theater is leveled in the aftermath of a natural gas explosion, which the team learns was caused by a hacker who could trigger further explosions. The team continues to mourn the loss of LaSalle.
Sebastian summons the team to offer their assistance with a potential kidnapping case when the son of a dignitary goes missing from a local concert venue. Wade investigates when a woman is abused.
When LaSalle's accused killer, Eddie Barrett, is released after providing an alibi witness, Pride and his team continue to gather evidence and discover Barrett controls an armed cult.
Pride becomes a hostage at Barrett's plantation near Jeanerette. There is a standoff between the cultists and the NCIS/FBI with the media watching. Barrett, whose aim is chaos, had rigged the house to explode but Sebastian foils that. While everyone else is arrested Barrett escapes through a tunnel. When Pride catches him, Barrett threatens Pride's family, which provokes Pride into killing him, though he tells his team that Barrett was reaching for his weapon.
The team is concerned when Sebastian becomes unreachable while undercover as a new recruit for an organization specializing in coordinated terrorist attacks.
The team must track down a mysterious assassin responsible for murders in Athens, Rome and London. Also, Wade's son begs her to allow him to go on a police ridealong for an article he's writing on a youth outreach program at the NOPD.
The team investigates the murder of a JAG officer whose daughter had witnessed it. Pride immediately suspects that the daughter and her boyfriend might be the ones involved after he discovers that the victim had cut her out of his estate. Meanwhile, Sebastian begins his new NCIS training.
During a case, Pride announces that he's going on medical leave from the task force to figure out the memory that keeps him up at night. At the same time Pride announces Special Agent Quentin Carter as the newest member and the replacement for LaSalle to an icy reception.
Gregorio must protect an autistic teenage girl with a gift for research after her father is shot in their home. The rest of the team searches for a motive. Meanwhile, Pride brings his mother to his bar to get her to relive her memories.
The team investigates a man who pretended to be LaSalle and the prisoner he tried to free from jail. Pride's daughter comes for a surprise visit.
Racial tensions rise in New Orleans when a white NOPD officer shoots a black Navy officer he believed was carrying a weapon in the middle of a busy street party.
When a Navy sailor is found dead, the team tracks suspicious movements of people in his life prior to his death. Also, Hannah comes to terms with her daughter's relationship with her ex's new girlfriend Veronica (Katie Rose Clark).
When Sebastian is injured while unsuccessfully trying to prevent a kidnapping, NCIS races to find the missing woman and her abductors. Also, the team gets a peek into Agent Carter's personal life.
The team investigates the death of a Naval microbiologist whose hobby as a "myth buster" resulted in his death at the tentacle of a legendary bayou creature. Agent Khoury conducts an investigation into the previous actions of Deputy Director Van Cleef who recently demoted her for misguided allegations that she exhibited poor judgement.