Dr. Manning and Dr. Halstead treat a pregnant patient from a car accident and are forced to perform an emergency Caesarean section on her. Meanwhile, Dr. Choi adjusts to his new role as chief emergency resident, Dr. Reese accepts a psychiatry residency offer from Dr. Charles, and Dr. Rhodes is introduced to his new superior, Dr. Latham, who informs Dr. Rhodes he was not his first choice. Dr. Manning and new medical student Jeff Clarke connect, which infuriates Dr. Halstead.
Dr. Manning and Dr. Rhodes separately treat complicated cases involving sick babies, only to uncover that the two cases could actually be intertwined. Elsewhere, Dr. Halstead and Dr. Charles treat a homeless man with an upbeat disposition who sheds some valuable insight that prompts one of the doctors to learn a thing or two along the way. Dr. Choi has a Navy corpsman follow him for the day as they deal with the toll of gang violence in the city, while Dr. Reese tries to understand the delicate
Dr. Halstead treats Maggie's visiting sister Denise (guest star Alexandra Grey) after Denise crashes her car due to temporary blindness. Dr. Halstead discovers that Denise is transgender and has prostate cancer. Dr. Manning and fourth-year medical student Jeff Clarke try to treat a patient who does not speak English, Dr. Reese and Dr. Charles deal with a pregnancy case that is slightly unusual, and Dr. Rhodes performs a difficult heart surgery without the consent of his attending, Dr. Latham.
Dr. Choi has an elderly patient who needs surgery, but the patient's son is refusing per his father's previous instructions. Dr. Manning and Dr. Halstead deal with an epidemic when a virus is spread to multiple patients. Dr. Reese and Dr. Charles deal with a patient in heroin withdrawal with an overbearing mother who is later discovered to be the patient's pimp, part of a sex-trafficking ring. Dr. Charles' daughter becomes the newest member of the epidemiology department.
A car accident that occurs at the Chicago Marathon leaves a victim in critical condition and tests the mettle of Dr. Halstead, April and her fourth-year medical resident brother Noah, who must perform a difficult procedure in the field. A mother brings in her 8-year-old girl experiencing a sudden hearing loss and Dr. Manning is left to tend to the case, which takes a complicated turn. Dr. Choi deals with Olga, a woman who is malnourished, prompting him to bring in Dr. Charles to help assess the
Dr. Reese tries to help a previous patient, Danny, a teen involved in a sex trafficking ring, and turns to Dr. Charles and Detective Erin Lindsay (guest star Sophia Bush) to help him get out of it. Meanwhile, Dr. Manning works with a young cancer patient who has taken a turn for the worse, Dr. Halstead tends to a patient with a length of dead bowel, and Dr. Choi deals with a young patient who does experiments on herself by swallowing little metal objects.
Tensions arise between Sharon, Dr. Choi, and Dr. Manning when treating an old love interest of Sharon's with a fatal disease. Dr. Reese continues to help Danny, while Dr. Charles tries to prevent a surgery that Dr. Rhodes deems necessary. Meanwhile, Noah asks Dr. Halstead to do house calls for his app and April gets engaged.
Dr. Halstead and Dr. Manning deal with two warring brothers who are brought together when one finds himself in desperate need of a kidney. Dr. Reese's former patient Danny comes to a crossroad. Dr. Rhodes and Dr. Latham treat a 16-year-old girl with a genetic condition in need of surgery, but whose overprotective mother disagrees with that course of action. A convict with unusual intentions puts himself in the hospital and Dr. Charles meddles in his daughter Robyn's personal life, much to her di
Dr. Choi does everything he can to prevent a fight from breaking out when he treats two MMA fighters. Dr. Manning asks Dr. Rhodes for help when treating a patient with respiratory issues, while Dr. Charles and Dr. Reese discuss a patient in need of a heart transplant. Also, April discovers her TB medication may be affecting her pregnancy and Jeff shares a secret with Dr. Manning which leads Natalie to end their relationship.
Maggie admits the police officer who arrested her previously for obstruction of justice. When the officer later dies from her injuries, Trudy Platt (Amy Morton) asks for April to help with the officer's organ donations instead of Maggie out of concern for the officer's husband. Meanwhile, Dr. Halstead deals with a jockey with an eating disorder. Dr. Rhodes treats a past patient who needs a heart transplant, but she later reveals that she has relapsed.
Everyone feels the effects of working the graveyard shift. As the psych resident on call, Dr. Reese is forced to make multiple death notifications to patients' families. Much to Tate's dismay, April gets pulled into working an extra shift. Also, Sharon calls Dr. Rhodes to the hospital to tend to a panda bear that needs surgery and Dr. Halstead is shadowed by a resident, only to find out that he has been intoxicated while on shift.
Dr. Manning and Dr. Charles tend to a patient whose daughter has similar symptoms with no physiological cause. Meanwhile, Dr. Choi and Jeff are put in a dangerous situation when they X-ray their patient and find out that he has a loaded gun up his rectum; Dr. Reese tries to connect with the patient, but fails. Dr. Halstead finds it distasteful when Dr. Stohl follows him around with a camera while filming a promotional spot for the hospital and Dr. Latham reveals to Dr. Rhodes that he has been re
Dr. Manning treats a young cancer patient who has not been receiving his chemotherapy prescription, but later discovers that, by not taking his medication, the boy's immune system has become strong enough to fight the cancer itself. Dr. Choi, Dr. Charles, and Dr. Reese treat a woman who has an unusual personality disorder while Dr. Halstead and Dr. Robin Charles try to tend to a woman who refuses treatment. Elsewhere, Dr. Rhodes and Dr. Latham take a trip to another hospital to perform a rare me
The hospital is put on high alert after they become overwhelmed with patients involved in a multi-vehicle pile-up during a blizzard. Dr. Manning and Dr. Halstead force a patient to make a decision on whether her son or her nephew will receive a blood transfusion. Dr. Choi tends to a burn victim whose condition is deteriorating and tries to see through his dying wish to say goodbye to his wife. Meanwhile, Dr. Rhodes is forced to do an emergency cesarean section on a hemorrhaging patient and Dr. C
Dr. Rhodes tends to a patient who survived a fall from the 33rd floor of a building, resulting in a city-wide media sensation. April receives devastating news that her baby has no heartbeat on the same day that she tends to a patient with a failing heart alongside Dr. Halstead. Dr. Choi and Dr. Manning treat a paraplegic and discover that he is using an experimental treatment to try and reverse his paralysis. Also, Dr. Reese tends to a patient who helps out people in need.
Dr. Manning treats a comatose patient who was sexually abused and is now pregnant, but later discovers that the patient has been in a paralyzed state after a suspected stroke. After an educational visit to a psychiatric facility, Dr. Reese finds one of the teens there has harmed herself as a means to see her and soon comes to believe the patient was wrongly admitted to the psychiatric facility. Also, Dr. Rhodes and Dr. Latham operate on a young girl who collapsed mid-flight while Dr. Choi, April
The staff at Gaffney Medical Center mourn the loss of one of their own after a suicide. Dr. Choi and Dr. Halstead butt heads while dealing with a young patient whose symptoms mimic a stroke and Dr. Manning deals with a boy who fell into a freezing river. Also, April makes a serious decision about her relationship following her miscarriage.
Dr. Halstead makes quick and difficult decisions when tending to an Alzheimer's patient who was also his mentor in medical school. Dr. Rhodes performs a risky surgery on a young boy as an alternative to amputating his arm. Meanwhile, Dr. Charles and Dr. Reese tend to a patient who denies having suicidal tendencies. Also, Maggie takes an aggressive route when training a new nursing student and Dr. Reese continues to mourn the loss of Jason Wheeler. After re-watching a speech his stricken mentor g
Chaos hits the hospital when the computer system gets hacked by an unknown source that asks for a ransom to bring it back online. Meanwhile, Sharon has an awkward encounter when her ex-husband brings in his new girlfriend to get treated for an injury. Dr. Choi tries to locate a bullet fragment that has migrated from the original wound. Also, Dr. Reese feels Dr. Charles is pushing her out of psychiatry and Dr. Rhodes is concerned by Dr. Robin Charles' erratic behavior. After the computer system c
Dr. Halstead asks for Dr. Rhodes' help in admitting his overbearing father against his wishes due to a failing heart. Meanwhile, Dr. Choi deals with a teenage patient who desperately needs to control his sexual urges. Dr. Manning and Jeff Clarke tend to a child who they discover has been neglected by his overworked mother. Also, Dr. Rhodes asks Dr. Charles to confront Robin over her erratic behavior. Dr. Reese teaches a class of high schoolers the responsibilities of raising a child by using dol
Dr. Rhodes and Dr. Manning tend to a pregnant patient whose fetus is the cure to its sister's cancer. Meanwhile, Dr. Charles has Dr. Reese perform the psychiatric evaluation on his daughter Robin as a means of keeping his nose in the entire process. Also, Dr. Choi gets tough on April's brother Noah when a residency opens up.
Dr. Rhodes challenges Dr. Charles and other hospital staff over the proper treatment for Robin. Dr. Manning seeks help from Det. Halstead when a sensitive case involving a young girl turns into a crime. Dr. Choi and April work together on a conflicting case. Meanwhile, Goodwin helps a friend in distress and, after eagerly awaiting, the doctors are surprised to learn who the new med resident is.
Robin is admitted back to the psychiatric facility, but Dr. Reese takes a different approach to her treatment. She and Dr. Charles soon discover that she has a tumor causing her psychological outbursts. Meanwhile, Dr. Halstead and Dr. Manning work on a refugee patient. Also, April tries to avoid Dr. Choi following his pass at her. In the end, Dr. Halstead admits the truth to both himself and Dr. Shore when he finally decides to break up with her after prompting from his brother, Jay. Meanwhile,