Following the car accident, Dr. Manning suffers a traumatic head injury and Dr. Halstead blames himself. Trauma surgeon Dr. Crockett Marcel and Dr. Halstead are suspicious of Phillip when he claims he and Dr. Manning are engaged and tries to order Dr. Halstead away from her care and life. Dr. Rhodes believes Dr. Bekker caused his father's death, but the administration seems to suspect Dr. Rhodes. When they learn the insulin overdose contains traceable amounts of chromium, Dr. Bekker takes her ow
During a stormy night in Chicago, the power goes out at Gaffney and chaos ensues. Dr. Marcel and Dr. Sexton are forced to perform surgery in the dark. Dr. Manning gets trapped in an elevator with a patient who needs emergency surgery. Dr. Choi trains a new set of residents while Dr. Halstead, Maggie, and Sharon tend to a series of students who are having multiple seizures and suspect it might be an outbreak.
April and Dr. Marcel get off to a rocky start when tending to a patient who performed her own childbirth. Dr. Choi deals with a patient who has terminal cancer trying to deliberately end his own life. Dr. Manning treats a patient with second degree burns. Maggie trains a new nurse whose near-constant referencing of her credentials unnerves Maggie. Also, after falling and fracturing her wrist at home, Dr. Charles' wife Caroline wants surgery to repair it.
Panic and terror continues to ravage Chicago as more victims die from a deadly flesh-eating bacteria outbreak. The Chicago Police Department’s Intelligence unit investigates and suspects the outbreak might be an act of terrorism, as it is only affecting two hugely populated places in the city. Meanwhile, Sharon deals with the press and fumes when her complete remarks aren't included in stories. The episode ends with Dr. Halstead catching one of the University researchers destroying evidence, thu
Dr. Marcel and Dr. Choi don’t see eye to eye when treating a patient with chronic pain, with Dr. Marcel recommending surgery. Dr. Manning is forced to take a drastic measure when treating a child patient whose parents do not believe in Western medicine. Dr. Halstead tends to a patient who is dealing with shortness of breath. Meanwhile, Maggie continues her chemotherapy treatment, but contemplates revealing her diagnosis to the staff.
April and Dr. Sexton stumble upon an assault in progress in an alley. They take the victim to get checked out and discover that she was about to be initiated into a gang. Also, Dr. Manning continues to struggle to find a diagnosis for a young patient after consecutive misdiagnoses and comes to a crossroads in her relationships with both Phillip and Dr. Halstead. Dr. Marcel reveals his suspicions of Phillip to Dr. Halstead. Meanwhile, Dr. Choi and Dr. Charles tend to a patient who is transitionin
Dr. Halstead and Dr. Charles deal with a patient who believes that he is a vampire. Dr. Manning and Elsa Curry deal with a patient with respiratory issues. Dr. Choi's treatment of a military amputee is blocked when a group of military officers escorts his patient back to base. Meanwhile, Maggie meets a man while at chemotherapy and also hosts a crawfish party along with Dr. Marcel. Also, April and Ethan discuss having children in their future.
Maggie makes an unethical decision when she discovers that her new friend Ben has contracted measles. Meanwhile, Dr. Choi and Dr. Charles deal with a patient who is a social media influencer using his followers to make medical decisions on his behalf. Also, Dr. Halstead treats a patient with a new kidney, but discovers that it is failing her and she might have to go back on both the transplant list and dialysis. Also, Dr. Marcel operates on April's brother, Dr. Sexton, after he is violently assa
As Dr. Manning treats Phillip's daughter, who he has abandoned, she begins to regain her memory of the night of the accident with Dr. Halstead and realizes she made a mistake, especially after the baby's relatives declare Phillip to be a far less than truthful man. Meanwhile, April receives news that she has a low chance of conceiving a child naturally, putting her relationship with Ethan at risk. Maggie is hopeful when her boyfriend Ben's health begins to improve. Also, Dr. Charles continues to
April deals with the fallout from her kiss with Dr. Marcel and considers telling Ethan. However, she gets surprising news from Ethan himself. Meanwhile, Dr. Halstead tends to a patient he dealt with in the past who now suffers from a drug problem. Dr. Manning treats a child of one of Dr. Halstead's patients. Dr. Curry tries to use an unorthodox phone app when treating a patient with panic attacks. Also, Dr. Charles mourns the loss of his wife CeCe.
The team at Gaffney Medical Center is put on high alert when a plane crashes at O'Hare Airport with one of their own, Dr. Abrams, listed as one of the victims. As Dr. Marcel and Dr. Choi tend to the unidentifiable patient's treatment, Abrams' wife shows up and immediately wants to pull the plug. Meanwhile, Dr. Manning finds a baby alone in a freezing car and later discovers that the child belongs to the COO, who is going through a divorce. Dr. Sexton and April tend to a patient who gave birth to
Dr. Marcel and Dr. Manning make difficult decisions when two children are impaled by rebar at a school bus accident. Meanwhile, Dr. Halstead's side project begins to take a toll on his position when Dr. Charles gets involved. Also, Maggie treats an old friend.
April, Dr. Choi, and Dr. Charles try to put the pieces together when a child is brought to the ED by his parents with severe bruising on the hands. Meanwhile, Dr. Manning grows suspicious of a mother who shows no emotion when her child is diagnosed with an intestinal condition. Also, Dr. Halstead is shocked to discover that one of his addicts is a doctor in the ED.
Dr. Manning and Dr. Marcel disagree over a patient involved in a domestic dispute. Dr. Charles and Dr. Curry step into the treatment of another doctor's patient, who is in a vegetative state, when they suspect that he may have been misdiagnosed. Dr. Halstead’s involvement at a safe injection site comes to a standstill. Also, Dr. Choi and April treat a patient who is allergic to her husband's semen.
Dr. Manning and Dr. Charles deal with a patient who is an actor pretending to be the father of a child at the mother's behest. They soon discover that the patient is intentionally poisoning himself as a part of his act. Dr. Choi and Dr. Marcel have differences when dealing with a prisoner patient on death row. Dr. Halstead grows worrisome about Hannah’s intent to give up opioids. Also, April and Dr. Sexton race against the clock, treating a patient who must keep running to sustain an elevated he
Dr. Marcel and Dr. Manning are kidnapped at gunpoint and forced into a van to help mend an escaped convict's broken leg. Meanwhile, Dr. Charles and Dr. Halstead are on opposite sides when dealing with a teenage patient exhibiting signs of schizophrenia. Dr. Choi and April discover the truth about a patient's scam. Dr. Halstead deals with the fallout from turning in Hannah. Also, Maggie receives news that she is in remission.
Dr. Manning and Dr. Charles tend to a child patient and suspect that the mother might be abusing her to get attention. After his daughter is suspended for vaping, Dr. Charles is forced to bring his daughter to the hospital. Meanwhile, after April begins to exhibit major stomach pains, Dr. Halstead recommends returning Dr. Asher. April reveals to Ethan that she kissed Crockett and Ethan and Marcel come to blows. Also, Maggie plans her wedding.
Sharon and Dr. Charles fear that Dr. Halstead is reverting to old habits when he begins to mistreat a patient with early onset Alzheimer's. Meanwhile, Maggie and Ben are worried about one of Ben's students when they discover that he hasn't been receiving treatment for his stomach. Dr. Manning and Dr. Marcel disagree over a patient regarding a difficult surgery. Also, April and Ethan's relationship begins to deteriorate following the fallout of April's confession.
Dr. Charles and Dr. Choi tend to a patient who fell off an overpass and Dr. Charles suspects that he might be suicidal, not a suspect in an investigation. Dr. Choi is forced to cross paths with Dr. Marcel and his patient, who is the key witness for the incident. Meanwhile, Dr. Halstead and Dr. Asher's relationship is put to the test when dealing with a pregnant patient who had brain cancer. Also, Maggie tries to cut through red tape in getting treatment for Ben's student. Meanwhile, things escal
Dr. Marcel’s past comes to Chicago when two detectives from New Orleans issue a warrant for his arrest in connection to a cold murder case. Meanwhile, Dr. Halstead discovers that his patient is using a false identity to receive medical treatment after he has a life threatening allergic reaction. Dr. Choi puts his life in danger to treat a child with a gunshot wound. Also, while his daughter volunteers at the hospital, Dr. Charles deals with a patient who is intentionally stabbing himself with ne