Dr. Manning departs Chicago and Dr. Halstead returns to Gaffney at the request of Sharon to investigate a fellow doctor (Dr. Cooper) suspected of taking kickbacks. Meanwhile, Gaffney welcomes Dr. Dylan Scott and Dr. Stephanie "Stevie" Hammer, the latter having known Dr. Halstead since medical school. Dr. Archer and Dr. Charles deal with a set of twins who do everything together inside and out. Dr. Scott treats a child patient with sickle cell anemia. Note: Final Main Appearance of Dr. Natalie Ma
Drs. Hammer and Halstead have a disagreement while dealing with a patient with Addison's disease whose mother is determined to do anything to protect him from unnecessary treatment. Drs. Taylor and Archer are at odds about treating a motorcycle accident victim. Drs. Scott and Charles deal with a UNICEF negotiator with repressed trauma. Meanwhile, Dr. Halstead continues his investigation into Dr. Cooper receiving kickbacks. Sharon's health is in jeopardy when she begins to experience dizzy spells
Dr. Hammer is put into an uncomfortable situation when the husband of a patient, and one of the hospital's biggest financial donors, acts inappropriately towards her. Drs. Halstead and Scott treat a patient who is lying about having lupus. Drs. Taylor, Charles, and Marcel try to convince a patient to agree to lifesaving surgery.
Maggie, Dr. Hammer, and Dr. Taylor are skeptical about a patient who claims to have terminal cancer. Dr. Hammer runs tests and discovers that the patient is cancer-free. Drs. Charles and Scott deal with a previous patient with schizophrenia. Dr. Halstead continues his kickbacks investigation into Dr. Cooper by presenting a new idea for the hospital.
Drs. Halstead and Hammer put their differences aside to treat an elderly patient. Drs. Charles and Scott deal with a patient who was misdiagnosed with ADHD. Dr. Marcel is forced to jump through political hoops while treating a patient who is the family member of another physician.
When her mother is admitted to the hospital, Dr. Hammer enlists help from Dr. Taylor so her mother will agree to seek treatment. Dr. Scott's police past comes back when he recognizes his patient's father, who he arrested 10 years prior for domestic violence, and suspects his daughter's injuries are not accidental. Dr. Marcel is forced to pick sides when it comes to a patient who needs a liver transplant. Also, Sharon continues to press Dr. Halstead over his investigation into Dr. Cooper.
Dr. Ethan Choi returns to Gaffney after his near fatal shooting accident and tries to adjust. Dr. Marcel tends to a patient in need of a liver transplant. Dr. Halstead continues the corruption investigation into Dr. Cooper.
Dr. Scott's life as a doctor and his past life as a police officer are put to the test when a family friend and a veteran is investigated by the police. Maggie lends a hand to Dr. Taylor when the hospital announces new random drug testing. Dr. Choi puts his recovery at risk when tending to a patient. Dr. Halstead helps Dr. Hammer search for her mother after she goes missing.
Dr. Halstead's investigation into Dr. Cooper reaches a stalemate when the hospital won't go to the FBI. At the same time, he helps Dr. Scott with a 4-month-old patient. Meanwhile, Dr. Taylor struggles to keep her addiction a secret. Drs. Marcel and Blake join Dr. Abrams for a liver transplant.
Sharon deals with the fallout of the Vascom scandal, leading to new hospital personnel. Meanwhile, Drs. Marcel and Blake tend to a patient with severe autism. Also, a patient’s child lies to the hospital about his father's injuries.
Drs. Marcel and Blake are at odds when trying to figure out which of their respective patients will receive a new liver. Dr. Scott's past comes to light when he reunites with a patient with whom he was previously romantically involved. Drs. Hammer and Charles team up to help a patient who fell in an alley.
Drs. Hammer and Halstead deal with a pregnant patient in need of an emergency C-section who only wants a blood transfusion with COVID-19 vaccine-free blood. Meanwhile, when Dr. Blake and her entire team mysteriously collapse in the middle of an operation, Dr. Marcel is forced to take over, leading Sharon to join as the OR Nurse. Dr. Charles visits Dr. Choi and encourages him to reconcile with his dad.
Drs. Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Drs. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a patient, Dr. Marcel takes a risk.
Goodwin assigns Med’s new compliance officer to a patient with a long-hauler COVID condition. Maggie helps Dr. Halstead treat a patient who's been in an iron lung for 60 years. Dr. Hammer learns hard truths about her mother. Terrell returns to Med under dire circumstances.
Dr. Scott suspects his patient may be a drug dealer. Dr. Halstead must decide how to spend his whistleblower settlement. Drs. Charles and Taylor help a patient who believes she's infested with parasites. Drs. Marcel and Blake are paired with an arrogant surgeon.
Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient's daughter is having an arranged marriage.
Drs. Halstead and Charles work with a teenage brain cancer patient who's refusing treatment. A patient's transplanted uterus fails, causing the doctors to consider transplanting one from her sister.
Archer and Asher clash over a patient with close ties to Goodwin. After a patient is shot during a home invasion, Scott and Marcel help with the investigation. Maggie and Halstead work to protect a patient who is in the country illegally.
Drs. Halstead and Asher work to save a surrogate's baby. Dr. Charles cares for a patient on a hunger strike. Dr. Scott and Maggie are confused over a supposedly sober patient who presents as drunk.
Dr. Scott helps the daughter of a mob boss. A grandmother comes to Med desperate to save her grandson. Dr. Choi struggles with shocking news about his father. Drs. Halstead and Taylor care for Maggie's high school classmate.
Drs. Scott and Choi treat a patient shot during a drug raid. Drs. Charles and Taylor work together to properly diagnose a motivational speaker. Drs. Halstead and Asher turn to Dr. Marcel for help with a pregnant patient.
Halstead and Asher clash over a patient in need of a kidney transplant. Marcel faces a tough decision when Blake is in surgery. Choi and Archer treat the son of Med's general counsel. Med's family grows.