On the way to begin his surgical residency at San Jose St. Bonaventure Hospital, Dr. Shaun Murphy witnesses an airport sign fall and shatter glass onto a young boy. With his unique ability to visualize the internal body and using improvised methods and tools, Shaun is able to stabilize the boy. In a hospital board meeting, Dr. Aaron Glassman, president of the hospital, tries to convince the board to hire Shaun, despite his autism. Throughout the episode, flashbacks are shown, revealing Shaun's c
Dr. Neil Melendez is doing rounds with Dr. Claire Browne and Dr. Jared Kalu. Melendez calls out Shaun for arriving late on his first full day. A middle aged woman is brought into the ER with abdominal pain. Shaun immediately diagnoses a malignant tumor. As punishment for lateness, Shaun is assigned 'scut work,' where his attention to detail gets him in trouble. After rechecking a discharged young girl's test results, Shaun races to her home, annoying her parents over the late hour but eventually
Shaun and Claire fly to San Francisco Municipal Hospital to get a liver for a transplant patient. After learning the helicopter can't take off due to bad weather, they resort to a police escort. During this, Claire learns to communicate with Shaun, bonding with him in the process. Meanwhile, at St. Bonaventure, Chuck, the recipient of the liver, is discovered to have alcohol in his system, a development that could void his transplant eligibility. Chuck later confesses he had one drink at his dau
Barb Allen, 22 weeks pregnant, and her husband arrive at St. Bonaventure, hoping the doctors can save their baby. A large non-cancerous tumor is growing on the fetus and must be removed in order to save his life. Despite the serious risks both to her and the baby, Barb insists on surgery. Meanwhile, Shaun and Claire are assigned a patient, Olivia, who has a boil in her genital area. However, when doctors attempt to drain it, a fibroid tumor is found to be wrapped around a nerve. The surgery to r
Shaun notices a young boy, Evan, who has an uncanny resemblance to his deceased brother Steve. Evan was brought to the hospital by his parents for a possible fracture to his arm. However, it is discovered that he is actually suffering from terminal bone cancer, a fact his parents have kept hidden from him. Shaun attempts to find another diagnosis and save Evan, earning him the scorn of his colleagues. Evan's terminal cancer diagnosis is ultimately confirmed with the revelation that it has metast
Shaun and the rest of the residents are working the graveyard shift when numerous casualties from a wedding bus crash arrive. Among the victims is a woman with severe visible burns on whom Jared tries an experimental procedure and a young man with a severely damaged leg. Tensions arise between the patient's parents and fiancée over the best choice for treatment; his parents want to amputate the leg, but his fiancée is in favor of an experimental bone-replacement procedure. Due to Jessica filing
Shaun encounters Liam, an autistic patient, when he is admitted to the hospital. Having to face prejudice from the young man's parents, Melendez defends Shaun for the first time and acknowledges his exceptional abilities. After Liam voices his support for Shaun doing the surgery, his parents allow it. Melendez allows Shaun to take a more active role in the surgery and Shaun saves Liam's life during a dangerous part of it. In the aftermath, Shaun helps Liam's parents to see how their overbearing
A robbery takes place while Shaun is shopping at a grocery store for apples. With Shaun's communication limitations, he puts the lives of two customers on a first date at risk, leading to a young woman getting shot. Shaun's neighbor Lea hugs him after he admits that he made a mistake and got someone hurt; though he doesn't hug back, he is shown to relax in her embrace. During surgery, Lim questions Claire's ability to not let her emotions get the better of her because of a racist patient, the sh
The team takes on the case of a young boy from the Congo who has severe congenital heart anomalies. Working together, Shaun and Melendez devise a procedure to treat the boy; despite difficulties, it is ultimately successful. Shaun's latest encounter with his neighbor Lea has him confused. He takes flirting lessons from Claire, noting and charting what he sees in regards to the "flirting trifecta." Meanwhile, Claire, along with Dr. Carly Lever, searches for a misplaced tissue sample from a woman
Shaun reluctantly agrees to Dr. Glassman's repeated suggestions to meet with a therapist, but ultimately changes his mind after a new patient, Bobby Ato, convinces Shaun to stop letting people tell him what to do. Claire runs into an uncomfortable situation when Dr. Matt Coyle makes unwanted sexual advances toward her during a patient consultation. Jared finds out and physically threatens him. As a result, Jared is fired. After a tense dinner with her father and Dr. Melendez, Jessica states that
Shaun and Lea embark on an impromptu road trip. Shaun experiences many firsts: driving, drinking tequila, singing karaoke, and even his first kiss with Lea. However, during the trip, Lea states her intention to move home to Hershey, Pennsylvania, which devastates Shaun. Melendez and Andrews operate on conjoined twins, one of whom needs a kidney. Complications develop and the operation to separate them, planned for six months after the kidney surgery, must be done immediately. The operation goes
Shaun returns to the hospital after his trip and gives Dr. Glassman his two weeks' notice, intending to move to Hershey to be with Lea. The twins suffer complications from their surgery; Katie is not getting enough blood flow to the brain and Jenny's heart is failing. Despite the doctors' best efforts to save both twins, Jenny dies on the operating table. After allegations of racism by Kalu's lawyer, Jessica is forced to look into previous misconduct incidents at the hospital in which white doct
While treating a Muslim patient, Shaun senses she is lying and makes controversial claims about how she sustained her injuries. Melendez punctures the bronchus of the patient during surgery and is put under investigation after Shaun questions if his personal life is affecting his work. While Claire assists in Dr. Lim's surgery on a stroke patient who had an aneurysm, she learns that Coyle got a new job and a raise. They inform the patient's wife that he needs surgery or he will die, but she refu
The four residents, including the new Dr. Morgan Reznick, are paired off in competition: Reznick and Browne with Melendez, Murphy and Kalu with Lim. Murphy and Kalu are faced with a transgender patient, Quinn, which leads to friction from Murphy's lack of experience and understanding relating to transgender people. Murphy and Kalu determine that she has testicular cancer. Browne and Reznick tend to a male patient that has contracted a superbug resistant to all medication as a result of taking le
A female teen goes through a risky surgery to implant a sternum so she can live a normal life without being confined to her house. A young boy initially rejects the idea of having a convicted killer's liver transplanted in him but, without it, he has a day to live. A former 15 year veteran cop-turned-doctor, Alex Park, is skeptical of the convict, Boris', motives. Allegra talks to Dr. Andrews about a young wealthy donor, Aidan Coulter, but Andrews says being involved with him might give people t
Shaun, Claire, and Alex assist Melendez with one of his first patients, a man named Hunter who was paralyzed in a motorcycle accident ten years prior. Jared, Morgan, and Andrews attend to a patient with an infection caused by plastic surgery. Claire's estranged mother shows up at the hospital saying she wants to reconnect but, in reality, she takes advantage of Claire once again. Andrews sees an infertility specialist that tells him there is a surgery that could help him with his sperm count, bu
Shaun and Alex treat teenaged Gretchen's Möbius syndrome, enabling her to smile; Andrews persuades an insurance executive to cover the surgery. After Gretchen fails to wake up, it is believed that she has become brain dead, but Park realizes that a rare condition is causing her to remain under anesthesia and she recovers. Morgan and Claire's patient, "Lucy Callard," is actually an identity thief who let her insurance lapse to pay her son's college tuition and failed to fill her post-operative an
Glassman tells Shaun about his inoperable glioma and that he has 18 months left to live. He accepts his death, but agrees to additional imaging for Shaun's sake; this yields a worse prognosis of four months to live. Glassman takes Shaun to a park his late daughter loved so they can enjoy the time Glassman has left. Shaun determines how a minimally invasive biopsy could be performed, which later proves that Glassman's cancer is operable and, though it'd be a long road to recovery, he'll most like