The hospital struggles against the COVID-19 pandemic and forces changes on the way everyone lives: Shaun and Lea are obliged to remain apart, Park is staying with Shaun, Glassman works from home, and Andrews sleeps in his garage to protect his wife. The situation takes its toll on everyone: Shaun struggles with being so far from Lea, Glassman becomes overprotective of Debbie to the point of annoyance, and Lim and Claire become short-tempered. The episode primarily focuses on three COVID patients
Claire deals with her grief by returning patients' belongings to their families while hallucinating Melendez. Claire tracks down the owner of a set of dog tags left behind by a deceased patient and, with the encouragement of Melendez, decides to begin moving on with her life. At the same time, Lim struggles with the increasing losses of patients to COVID-19, Park continues to treat his formerly pregnant patient, and Shaun and Andrews attempt to save a man who must have his right foot and ankle a
Shaun, Claire, and Park are assigned to supervise six resident applicants with only four positions available while Morgan struggles with the transition to internal medicine. Andrews, Shaun, and Park treat a seventeen year old getting breast implants to fix a deformity; while the surgery is initially successful, she experiences complications that put her into a coma. It is determined that the patient formed a blood clot in her brain, but Andrews manages to remove it using a stent retriever. Morga
While treating Billy Carr, one of Morgan's patients, Asher discovers that Billy has skin cancer instead of an ingrown hair. Despite some complications, Billy pulls through. Shaun and his junior residents Olivia and Jordan treat Kenzie, a pregnant woman with twins whose own body is trying to kill one of her unborn children. Shaun comes up with the solution of delivering the stronger twin and then stopping labor so that the weaker twin can grow; despite some troubles, the plan succeeds. Shaun stru
Claire, Park, Enrique, and Jordan treat Ellie, a young woman who has both a husband Brendan and a new weeklong relationship with boyfriend Zane; the polyamorous Enrique takes Ellie's side in the matter. The team removes a dermal cyst, but it causes memory issues with Ellie, threatening the memories of her relationship with Zane; Enrique solves the matter by having Ellie film a message to herself pre-operation and, with full knowledge of her affair, Ellie ultimately chooses to remain with Brendan
Lim and Claire treat Ben, a military veteran suffering from PTSD; the two agree to perform an experimental procedure for his condition after Ben nearly commits suicide. After losing Carl, Shaun, struggling with guilt along with Asher, refuses to train residents; Lim later has Shaun and Asher perform Ben's procedure together, which proves to be successful in that Ben can finally open up about his trauma. Lim assigns Jordan to perform an abortion despite her reluctance due to her religious beliefs
Claire, Jordan, and Olivia treat a woman with a history of cancers and a venture capitalist husband who has been overworking himself to cope with his fears of losing her; after the woman is diagnosed with Li–Fraumeni syndrome, a genetic predisposition to cancer, Claire suggests he help his wife through her treatment before divorcing her. At the same time, Andrews, Park, Shaun, Asher, and Enrique treat a man who is attempting to extend his life using CRISPR gene editing, but caused a series of di
Shaun, Asher, and Enrique treat Darya, a young gymnast with a distant relationship with her father and who needs spinal fusion surgery that would ruin her career. At the same time, Andrews, Jordan, and Olivia treat Darya's father who suffers from a ruptured esophagus. Andrews encourages Olivia to be more aggressive in her interactions and treatment of patients; Olivia later asserts her independence from Andrews' view of her. Lim forces Darya to see the impact of her choices and she reconciles wi
Claire, Enrique, and Andrews treat Zara, an African-American medical marijuana dispensary owner; after racially profiling Zara upon admission to the hospital, Claire's mistake nearly kills her. Despite being removed from the team for the surgery, Claire's insight saves Zara's life; Claire later makes amends with Zara, who helps Claire realize that she has spent her life adjusting her behavior to make white people comfortable, something that greatly bothers Claire along with the revelation that A
The hospital suffers a cyberattack from hackers who demand $2 million or they will destroy the hospital's data and imaging machines. After figuring out how to repair the servers, Lea concludes that the hackers are bluffing, but she is left struggling on whether to act; Glassman orders her not to take the risk. Lea restores the system anyways, proving to be correct; although Glassman is angry, Lea earns his respect. Morgan, Park, Asher, and Jordan treat Jamie, a young woman with Down syndrome who
Morgan and Shaun treat Dannie, a woman comatose for ten years following a brain aneurysm whose husband Elias can't bear to let go. After they remove a tumor, Dannie unexpectedly regains consciousness, but the situation is only temporary; at Morgan's suggestion, Dannie signs a DNR. Park, who is still living with Morgan, is burdened by Glassman's rejection of having him on the surgical team. Glassman, Andrews, Claire, and Asher treat Jeffrey, a young man with ankylosing spondylitis. A complication
Shaun, Claire, and Enrique treat surgeon Silas Chambers, who demands that the team perform a risky surgery so that he can continue his surgical career. Shaun thinks that Chambers is also autistic and attempts to convince him not to have the surgery, but Chambers chooses to do it; the surgery is a success and Silas thanks Shaun and Enrique. Morgan, Park, Asher, and Lim treat Oscar, who feels intense pain at the slightest touch to his face; Morgan and Park disagree over his treatment, but come tog
Maya Flores, a dancer who suffers from bleeding after a collision with an elbow, is rushed to surgery shortly after her arrival, as her bleeding is not clotting. After surgery, she tells the team that her right leg has been bothering her for months and Shaun proposes taking X-rays of her hip and femur in order to rule out a possible fracture. Wolke tells her a personal story in order to coax her into not risking her life by continuing her dance career. Come the next surgery, she starts rejecting
Morgan, Park, and Asher treat Bradley Vargas, an MMA fighter with breast cancer; Bradley chooses a debilitating chemotherapy treatment rather than the mastectomy that he needs due to fears of ruining his image, but Park convinces him to have the surgery. Shaun, Claire, and Jordan treat Jean, a Naval aviator who has complications during hip replacement surgery that prove to be difficult to diagnose; after learning that Jean's regular doctor dismissed many of her symptoms as being from menopause,
At a protest, two boys, Ethan and Mason, are shot in the head and chest respectively and rushed to St. Bonaventure. Their mothers, Taryn and Carina, are supported by Lea, who is awaiting results on a gestational diabetes test; however, the two women argue over their differing political views. While the initial surgeries are successful, Mason experiences a complication requiring a blood transfusion, but the hospital lacks enough blood; Taryn donates some of her own and Mason survives. Ethan is di
An elderly woman named Maxine is rushed into St. Bonaventure after collapsing at an Art Nouveau event. After flatlining and then coming back to life, the staff discovers she is terminally ill and has a heart implant meant to keep her blood pumping should her heart stop. She then elects to have surgery to remove the pump, having signed a DNR, but an infection takes hold. Maxine refuses antibiotics in order to facilitate her death. However, Asher, after losing his grandmother without a chance to s
Claire, Lim, and Morgan treat Claire's idol, Senator Marian Clark, who has a brain aneurysm and is more worried about her image than being truthful to her husband. Shaun refuses to take time off of work, which causes him to brashly accuse Dr. Paul Nakano of making a mistake during patient Artie Hill's bypass surgery that's causing his mild heart failure. Shaun later realizes that he was wrong about Paul having made a mistake but right about there being a problem and he stops the surgery just in
Shaun surprises a grieving Lea with a camping trip. When they arrive at Yosemite, they are turned away. They arrive at a new campsite, where they struggle to acclimatize to the outdoors. The next morning, during a planned hike, Shaun falls off a log, seriously injuring his ankle. Lea performs emergency surgery on him using a tent repair kit and a fish hook to save his life. Claire tries to avoid a conversation with her father about their past. Claire and Lim treat a 12-year-old girl with a growt
The doctors travel to Guatemala to perform 12 surgeries on patients who would otherwise die. Andrews enlists Shaun's help to come up with a surgical plan after bonding with a young boy, Bastion, who requires a complex surgery to remove a tumor. Claire bonds with Edna, a single mother with gallstones. Morgan is devastated by having to reject a young boy as a possible candidate and refuses Park's attempts to comfort her. Lea continues to struggle with the loss of her baby and tells Shaun that she
The doctors begin performing the surgeries while hampered on the first day; after revealing that his wife is seeing someone else, Andrews gives up his wedding ring to pay for the supplies to successfully complete surgery on Bastion. Claire's patient, Edna, is diagnosed with gallbladder cancer; when Edna develops complications, Shaun encourages Claire to trust her own instincts and she saves Edna. One of their patients reinjures himself at work and Morgan must operate herself; despite experiencin