Shaun and Lea clash over how to handle baby Steve, who is now two weeks old. Shaun returns to work and joins Lim in treating baby Jack Pierce, who desperately needs a new heart. However, complications arise when Morgan's adopted daughter Eden needs a new heart, as well. Shaun is forced to make the difficult decision to give the heart to the sicker Jack, but he comes up with a plan to transplant Jack's healthy valves into Eden in order to save her. Although there are some minor complications, bot
Shaun, Jared, Jordan, and new autistic med student Charlie Lukaitis treat a man named Rich who has silicosis and needs new lungs. Charlie idolizes Shaun, but her constant mistakes rub Shaun the wrong way. Charlie finds out that Rich's daughter Grace is a sex worker, which causes Rich to back out of the surgery when she tells him. Shaun convinces Rich to accept his daughter, regardless of what she does for a living. Park, Asher, and another newbie, Charlie's friend Dominick Hubank, deal with Sal,
Phipps is a college student who injured his head during a fraternity party. Shaun becomes irritated by Charlie's impulsive behavior, but she refuses to admit any wrongdoing. Lim and Glassman's differing work methods to appease the hospital board cause them to give conflicting advice to Shaun on how to handle Charlie. As he is about to perform surgery on Phipps, Charlie asks to feel the gall bladder and finds a sharp item in it, leading to the realization that Phipps has metal shards in his body;
38-year-old patient Cameron has early-onset Alzheimer's and crashed his car. His wife Gilly is pregnant and fears taking care of both him and the baby will be too much for her. Shaun determines Cameron is instead suffering from a compressed jugular, which can be corrected with surgery. Jordan, Jared, Park, and Charlie try to help Nathan, a friend from Jordan's church choir, whose hearing he fears will be affected by the removal of a benign brain tumor. Charlie's AI research ultimately proves to
At Lim and Glassman's insistence, Shaun reluctantly agrees to work with Charlie. Along with Jared, they treat Lucy, a morbidly obese 14-year-old girl. Lucy agrees to a gastric sleeve surgery but, when Charlie lists the risks without pointing out their unlikeliness, Lucy and her mother decide against the surgery, angering Shaun. Charlie is able to change their minds by opening up about receiving accommodation for her condition at school. Charlie makes another mistake during the surgery, resulting
Still reeling from Asher's murder, the hospital has to deal with a man driving his car through a crowd whilst half the hospital is away at a medical conference. As Lim operates, she places Shaun in charge as he won't let his emotions get in the way, but Lim struggles with losing her patients, including one who resembles Asher. Lim's mother later reveals that her father had secretly suffered from clinical depression, something that she's worried Lim might have as well. Taking her mother's advice,
Naomi is a mother in need of a kidney transplant. A man named Emmanuel volunteers to donate his kidney, but Jordan is reluctant to proceed because he believes he is Jesus. Jordan unleashes her pain and anger over Asher's death on Emmanuel when he brings it up, having lost her faith in God. Shaun deduces that Emmanuel has a pheochromocytoma on his kidney, which explains his mental state. After waking up from his surgery, we learn his real name is Carl and he no longer wants to donate his kidney.
Park, Jordan, and Dom treat Mason, a botanist suffering from illnesses related to his time in space and who has a new outlook on life. Although Mason and his wife Ana are at odds about their future together, they find a compromise after Mason nearly dies. Shaun, Charlie, and Jared treat Tayo, a young boy with a third arm from his absorbed twin brother which is threatening his health. Shaun is able to come up with a way to use the nerves from the third arm to give Tayo a fully functional left arm
After discovering a lump in her breast, Claire returns to San Jose, where she's diagnosed with stage 1 breast cancer, receiving treatment from Shaun, Jared, and Charlie. Lim, Jordan, and Dom treat Clint, a man diagnosed with a brain tumor after being struck by lightning. Clint plays guitar during the successful surgery to remove the tumor to help keep track of his motor skills. Glassman continues to secretly treat Hannah, although it takes an emotional toll on him. After receiving advice from Cl
Glassman reveals that he has three to six months to live and Shaun desperately tries to find a solution, despite Glassman's refusal to undergo treatment. Claire is diagnosed with an antibiotic-resistant acinetobacter infection, forcing them to put Claire into a coma and amputate her left arm as her condition worsens. Shaun and Charlie devise an experimental bacteriophage treatment, which Glassman gives to Claire so that Shaun won't have to sacrifice his career after the FDA refuses to approve it