In performance reviews, Andrews, now president of the hospital, tells Shaun to learn to communicate, Claire to be more assertive, and Morgan to improve her teamwork. Jared, working his last day before moving to Denver, skips his. Jared and Shaun run a mobile clinic and meet Harry, a mentally unstable homeless man. When Shaun takes Jared's advice to spend time with Glassman, who is beginning his cancer treatment with Dr. Blaize (his last hire before being replaced), it leads Shaun to diagnose Har
Shaun and Claire assist Dr. Melendez in treating Paul, a hospital janitor Shaun has diagnosed with pancreatic cancer and one year to live. Paul's wife and adult children encourage him to have risky surgery; Paul agrees, telling Shaun he wants to please his family and advising Shaun to lie when the truth is unhelpful. Paul dies from a complication and his family begins to squabble over having coerced Paul; Shaun lies, telling them that Paul wanted the surgery. Dr. Lim treats Mara, a sixteen-year-
On 36-hour shifts, Shaun and Morgan manage the emergency room in Dr. Lim's absence while Claire and Alex assist Dr. Melendez. Melendez performs surgery to treat a woman's endometriosis and restore her fertility. Her condition is more severe than realized and the planned hour-long surgery stretches to over 22 hours; tensions rise among Melendez, Claire, and Nurse Flores. When a risky procedure is the only way to avoid a hysterectomy, the patient's husband refuses to make a decision. He cedes the
Mac, a boy with fragile X syndrome, injures himself and his mother, Nicole. Alex and Shaun believe Nicole should send Mac to a group home; at Melendez's recommendation, Nicole agrees. Shaun recalls living with a tough-loving foster mother who became terminally ill. Dr. Lim, Claire, and Morgan treat injured 18-year-old female free solo climber Kitty; her parents, disapproving a risky surgery that could preserve Kitty's athleticism, obtain a declaration of medical incompetence and authorize a safe
Dr. Brown administers a Precordial thump. Dr. Lim treats Wade who, due to Crohn's disease and a fistula, must have his gastric bypass reversed. Wade keeps his past obesity secret from his husband, Spencer. Divorcées Alex and Lim disagree over marital honesty; Alex considers it more important. Wade tells Spencer he kept the secret because Spencer mocked their overweight friends. Spencer admits to Alex his unease at knowing Wade could regain the weight. Dr. Melendez treats Louisa, a mother with an
Now working with Dr. Lim, Claire treats a teenage girl, Riley, for severe respiratory problems. Riley's parents believe she is making herself sick over their divorce, but Claire suspects a tumor. When Riley's condition worsens, Claire convinces her parents to allow exploratory surgery; Park initially doubts Claire, but ultimately helps her. They discover and remove an inhaled Lego from Riley's lung; her years-long illness was an immune response to the foreign object. Shaun and Morgan disagree ov
Claire's college roommate Kayla has terminal ovarian cancer; Claire persuades Dr. Melendez to perform a pain-relief procedure and a life-extending treatment option emerges. At Kayla's insistence, Claire works on Melendez's team with Alex. Kayla asks her husband Dash and Claire to date if she dies, sending them to dinner together. Kayla wants Dash to be taken care of and Claire to open her heart. Claire accuses Kayla of being controlling; during the second procedure, Claire resolves a complicatio
Morgan and Park treat Finn, whose parents don't believe in vaccines. Finn has diastematomyelia, a congenitally split spinal cord. During Finn's treatment, his mother Bethany allows Park to vaccinate him. Finn is treated successfully, but Bethany acted without her husband's knowledge, threatening their marriage. In a failed effort to reconcile them, Park emotionally tells the husband a story (which Park later claims is untrue) of a family that fractured when a couple failed to address the wife's
Claire and Morgan treat George, a pedophile who has never acted upon his urges. The hormones that suppress his urges have caused a stroke; he must discontinue them. He mutilates his scrotum and asks the doctors to castrate him. Claire and Morgan eventually agree, but they and Dr. Melendez must instead repair his testicles to prevent unsurvivably low testosterone. George commits suicide; Morgan suggests the outcome is satisfactory. Alex and Shaun treat Billy, a severely beaten juvenile offender.
After sleeping together, Drs. Lim and Melendez agree not to do so again despite both having enjoyed it. The ER and its waiting room are quarantined after two patients, travelers returning from Malaysia, die of a viral respiratory disease. Those quarantined include Shaun, Morgan, Lim, and Alex's estranged son Kellan. Morgan treats Tyler, an infected EMT with whom she shares a developing romance; Tyler dies despite Morgan's impassioned efforts. Lim gets infected and isolates herself. Mall Santa Pe
Morgan revives Shaun by getting him to focus on Santa Pete's condition; with Shaun's help, Morgan successfully completes the surgery. Melendez and Claire revive their patient and devise a way to perform the bone marrow transplant with Andrews' help. Park breaks quarantine to treat Kellan's asthma attack and extracts Bob's bone marrow with the help of retired veterinarian Esther; the transplant is a success, but Bob dies of complications. Esther later conveys Bob's final regrets to his son. Morga
In the aftermath of the quarantine, the governor orders a review of the hospital; the investigator expresses concern about Andrews maintaining his dual role and recommends Shaun, Lim, and Melendez to the medical board for license suspension over their actions. With the ER closed for cleanup, Park spends the day with his ex-wife Mia and son Kellan, Morgan and Claire spend the day helping Claire's mother pack up her apartment, and Shaun and Glassman spend the day with Lea. Park and Mia decide to w
Claire, Park, and Melendez treat an elderly patient, Sunny, with an estranged biological daughter Grace and a surrogate daughter Teresa. Sunny's mechanical heart is malfunctioning. With her condition deteriorating, the doctors are forced to operate rather than send Sunny to her doctor in China; the surgery is a success. Afterwards, with support from Park and Teresa, Sunny and Grace begin mending their relationship. At the same time, Lim, Morgan, and Shaun treat an autistic patient, Lana, whose b
A 14-year-old girl, Karin, is left brain dead following a car accident and Andrews asks Karin's mother Shannon to consent to a face transplant for Molly, whose face was destroyed by an accidental gunshot. Shannon consents only after Claire arranges for Shannon to encounter Molly. Melendez, Lim, Andrews, Morgan, Park, and Claire perform a successful transplant. Melendez and Lim question their relationship, as Lim is concerned that Melendez has uncharacteristically deferred to her to the detriment
Glassman undergoes chemotherapy and rebuffs the social overtures of fellow patient Larry. He later embraces cancer as an identity and socializes with Larry and leukemia patient Candice. The hospital's new Chief of Surgery, Doctor Jackson Han, assigns Melendez to run tests on Minesh, a wealthy entrepreneur wanting a full workup. Melendez finds a spine tumor with a 95% chance of being benign but, if malignant, Minesh would soon die without risky surgery. Minesh decides to undergo surgery; the tumo
Glassman completes his chemotherapy and attempts to renew his relationship with Debbie. However, hurt by Glassman pushing her away while he was sick, Debbie rebuffs him. Melendez, Claire, and Morgan treat Clarence, a pastor with spinal cancer, who refuses a spinal fusion to fix his pain as he blames himself for a parishioner's suicide and thinks he deserves to suffer. After Clarence's cancer disappears without a medical explanation, Claire, who lost her faith at some point, convinces Clarence to
Han meets with the medical review board regarding the events of the quarantine and reaches a compromise where the hospital will pay some fines and Shaun, Lim, and Melendez will have to attend a few classes, but are otherwise clear of trouble. Glassman's final test results shows that he is completely cancer-free; after Glassman gives her a personal gift in thanks, Dr. Blaize suggests that his ordeal has changed Glassman for the better. Lim treats the newborn daughter of her old friend Laura who d
Morgan and Park treat an elderly patient, Ida; Alex proves Ida is faking post-surgery symptoms, but he apologizes to her after Morgan researches Ida's sad, lonely life. Shaun skips a job interview to drink at a bar where his rambling causes another patron, Zack, to attack him; Zack then collapses. An embarrassed Shaun conceals the altercation; Carly, his old pathology colleague, discreetly helps him diagnose his own internal injuries. Shaun realizes that Zack has been misdiagnosed; Shaun collaps